Pathophysiological effects of SARS-CoV-2 infection on the cardiovascular system and its clinical manifestations—a mini review

Frontiers in Cardiovascular Medicine

Cardiovascular Medicine

Heitor Moreno¹  Roberto Schreiber¹  Juan Carlos Yugar-Toledo²  Louise Buonalumi Tacito Yugar³  Luis Gustavo Sedenho-Prado³ 

[1] Department of Internal Medicine, School of Medical Sciences, State University of Campinas (UNICAMP), São Paulo, Brazil;Medicine Department, Faculty of Medicine of São José do Rio Preto (FAMERP), São Paulo, Brazil;School of Medical Sciences, State University of Campinas (UNICAMP), São Paulo, Brazil;

关键词: SARS-CoV-2;    cardiovascular disease;    myocarditis;    heart failure;    arrhythmia;    cardiogenic shock;   

DOI  :  10.3389/fcvm.2023.1162837

 received in 2023-02-10, accepted in 2023-04-18,  发布年份 2023

来源: Frontiers

【 摘 要 】

Coronavirus disease 2019 (COVID-19) is a viral infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 may have a mild presentation, with few symptoms, or progress to a severe condition, characterized by generalized inflammation, systemic microvascular involvement, coagulopathy, and pulmonary and cardiovascular complications. Men present with more severe symptoms than women, especially men who are older and who present with comorbidities such as hypertension, diabetes mellitus, and a history of atherosclerotic diseases. Owing to its association with endothelial dysfunction, inflammation, thrombosis, and microvascular obstruction, SARS-CoV-2 infection can cause lesions in several organs, including the myocardium and the coronary arterial bed, which can result in clinical manifestations involving the cardiovascular system. In this mini review, we summarize the effects of SARS-CoV-2 infection on the cardiovascular system in both children and adults and characterize the various clinical manifestations associated with this disease.

【 授权许可】

Unknown   
© 2023 Yugar-Toledo, Yugar, Sedenho-Prado, Schreiber and Moreno.