Fluid-solid coupling model and biological features of large vestibular aqueduct syndrome

Frontiers in Bioengineering and Biotechnology

Bioengineering and Biotechnology

Mengjie Luo¹  Can Zhou¹  Xiuzhen Sun¹  Xu Bie¹  Zewen Chen¹  Shen Yu² 

[1] Department of Otolaryngology, Head and Neck Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, China;State Key Laboratory of Structural Analysis for Industrial Equipment, Dalian University of Technology, Dalian, China;

关键词: large vestibular aqueduct syndrome (LVAS);    vestibular aqueduct (VA);    biomechanics;    fluid solid coupling;    sensorineural deafness;   

DOI  :  10.3389/fbioe.2023.1106371

 received in 2022-11-23, accepted in 2023-05-03,  发布年份 2023

来源: Frontiers

【 摘 要 】

Objective: Computed tomography (CT) images of the temporal bone of large vestibular aqueduct syndrome (LVAS) patients were used to establish 3D numerical models based on the structure of the inner ear, which are, in turn, used to construct inner ear fluid-solid coupling models. The physiological features and pathophysiology of LVAS were analyzed from a biomechanical perspective using finite element analysis.Methods: CT images of the temporal bone were collected from five children attending the Second Hospital of Dalian Medical University in 2022. The CT images were used to build 3D models of the inner ear containing the vestibular aqueduct (VA) by Mimics and Geomagic software, and round window membrane models and fluid-solid coupling models were built by ANSYS software to perform fluid-solid coupling analysis.Results: By applying different pressure loads, the deformation of the round window membranes occurred, and their trend was basically the same as that of the load. The deformation and stress of the round window membranes increased with the increase in load. Under the same load, the deformation and stress of the round window membranes increased with the expansion of the midpoint width of the VA.Conclusion: CT images of the temporal bone used clinically could establish a complete 3D numerical model of the inner ear containing VA. Fluctuations in cerebrospinal fluid pressure could affect inner ear pressure, and VA had a limiting effect on the pressure from cerebrospinal fluid. The larger the VA, the smaller the limiting effect on the pressure.

【 授权许可】

Unknown   
Copyright © 2023 Chen, Luo, Zhou, Bie, Yu and Sun.