Galectin functions in cancer-associated inflammation and thrombosis

Frontiers in Cardiovascular Medicine

Cardiovascular Medicine

Erika Cosset¹  Attila Braun²  Linus Kruk³  Elmina Mammadova-Bach³  Thomas Gudermann⁴ 

[1] CRCL, UMR INSERM 1052, CNRS 5286, Centre Léon Bérard, Lyon, France;Walther-Straub-Institute for Pharmacology and Toxicology, Ludwig-Maximilians-University, Munich, Germany;Walther-Straub-Institute for Pharmacology and Toxicology, Ludwig-Maximilians-University, Munich, Germany;Division of Nephrology, Department of Medicine IV, Ludwig-Maximilians-University Hospital, Munich, Germany;Walther-Straub-Institute for Pharmacology and Toxicology, Ludwig-Maximilians-University, Munich, Germany;German Center for Lung Research (DZL), Munich, Germany;

关键词: galectins;    cancer;    inflammation;    thrombosis;    anti-cancer therapies;   

DOI  :  10.3389/fcvm.2023.1052959

 received in 2022-09-24, accepted in 2023-01-12,  发布年份 2023

来源: Frontiers

【 摘 要 】

Galectins are carbohydrate-binding proteins that regulate many cellular functions including proliferation, adhesion, migration, and phagocytosis. Increasing experimental and clinical evidence indicates that galectins influence many steps of cancer development by inducing the recruitment of immune cells to the inflammatory sites and modulating the effector function of neutrophils, monocytes, and lymphocytes. Recent studies described that different isoforms of galectins can induce platelet adhesion, aggregation, and granule release through the interaction with platelet-specific glycoproteins and integrins. Patients with cancer and/or deep-venous thrombosis have increased levels of galectins in the vasculature, suggesting that these proteins could be important contributors to cancer-associated inflammation and thrombosis. In this review, we summarize the pathological role of galectins in inflammatory and thrombotic events, influencing tumor progression and metastasis. We also discuss the potential of anti-cancer therapies targeting galectins in the pathological context of cancer-associated inflammation and thrombosis.

【 授权许可】

Unknown   
Copyright © 2023 Kruk, Braun, Cosset, Gudermann and Mammadova-Bach.