Dose and time-dependence of acute intermittent theta-burst stimulation on hippocampus-dependent memory in parkinsonian rats

Frontiers in Neuroscience

Neuroscience

Jian Liu¹  Yixuan Wang²  Libo Li²  Zhongheng Wu²  Qiaojun Zhang²  Yanping Hui²  Xiang Wu²  Ling Wang²  Yihua Bai² 

[1] Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, Xi’an, China;Department of Rehabilitation Medicine, The Second Affiliated Hospital, Xi’an Jiaotong University, Xi’an, China;

关键词: intermittent theta-burst stimulation;    Parkinson’s disease;    hippocampus;    memory;    hippocampal theta rhythm;   

DOI  :  10.3389/fnins.2023.1124819

 received in 2022-12-15, accepted in 2023-02-02,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundThe treatment options for cognitive impairments in Parkinson’s disease (PD) are limited. Repetitive transcranial magnetic stimulation has been applied in various neurological diseases. However, the effect of intermittent theta-burst stimulation (iTBS) as a more developed repetitive transcranial magnetic stimulation paradigm on cognitive dysfunction in PD remains largely unclear.ObjectiveOur aim was to explore the effect of acute iTBS on hippocampus-dependent memory in PD and the mechanism underlying it.MethodsDifferent blocks of iTBS protocols were applied to unilateral 6-hydroxidopamine-induced parkinsonian rats followed by the behavioral, electrophysiological and immunohistochemical analyses. The object-place recognition and hole-board test were used to assess hippocampus-dependent memory.ResultsSham-iTBS and 1 block-iTBS (300 stimuli) didn’t alter hippocampus-dependent memory, hippocampal theta rhythm and the density of c-Fos- and parvalbumin-positive neurons in the hippocampus and medial septum. 3 block-iTBS (900 stimuli) alleviated 6-hydroxidopamine-induced memory impairments, and increased the density of hippocampal c-Fos-positive neurons at 80 min post-stimulation but not 30 min compared to sham-iTBS. Interestingly, 3 block-iTBS first decreased and then increased normalized theta power during a period of 2 h following stimulation. Moreover, 3 block-iTBS decreased the density of parvalbumin-positive neurons in the medial septum at 30 min post-stimulation compared to sham-iTBS.ConclusionThe results indicate that multiple blocks of iTBS elicit dose and time-dependent effects on hippocampus-dependent memory in PD, which may be attributed to changes in c-Fos expression and the power of theta rhythm in the hippocampus.

【 授权许可】

Unknown   
Copyright © 2023 Wang, Liu, Hui, Wu, Wang, Wu, Bai, Zhang and Li.