Preclinical models and evaluation criteria of prostatitis

Frontiers in Immunology

Immunology

Biao Qian¹  Guoxi Zhang¹  Hui Xu¹  Junrong Zou¹  Xiaofeng Zou¹  Fei Zeng²  Hui Luo³  Hailan He³ 

[1] Department of Urology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China;Institute of Urology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China;Department of Urology, Jiangxi Engineering Technology Research Center of Calculi Prevention, Ganzhou, Jiangxi, China;The First Clinical College, Gannan Medical University, Ganzhou, Jiangxi, China;The First Clinical College, Gannan Medical University, Ganzhou, Jiangxi, China;Department of Urology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China;

关键词: prostatitis;    chronic non-bacterial prostatitis;    animal models;    evaluation criteria;    infectious prostatitis;   

DOI  :  10.3389/fimmu.2023.1183895

 received in 2023-03-10, accepted in 2023-04-24,  发布年份 2023

来源: Frontiers

【 摘 要 】

Prostatitis is a common urological condition that affects almost half of all men at some point in their life. The prostate gland has a dense nerve supply that contributes to the production of fluid to nourish sperm and the mechanism to switch between urination and ejaculation. Prostatitis can cause frequent urination, pelvic pain, and even infertility. Long-term prostatitis increases the risk of prostate cancer and benign prostate hyperplasia. Chronic non-bacterial prostatitis presents a complex pathogenesis, which has challenged medical research. Experimental studies of prostatitis require appropriate preclinical models. This review aimed to summarize and compare preclinical models of prostatitis based on their methods, success rate, evaluation, and range of application. The objective of this study is to provide a comprehensive understanding of prostatitis and advance basic research.

【 授权许可】

Unknown   
Copyright © 2023 He, Luo, Xu, Qian, Zou, Zhang, Zeng and Zou