Frontiers in Medicine | |
Which are the most frequently involved peripheral joints in calcium pyrophosphate crystal deposition at imaging? A systematic literature review and meta-analysis by the OMERACT ultrasound – CPPD subgroup | |
Medicine | |
Lene Terslev1  Garifallia Sakellariou2  Silvia Sirotti3  Georgios Filippou3  Piercarlo Sarzi-Puttini4  Francesco Porta5  Helen Keen6  Carlos Pineda7  Antonella Adinolfi8  Nicola Ughi9  Edoardo Cipolletta1,10  Emilio Filippucci1,10  Maria Antonietta D’Agostino1,11  Anna Zanetti1,12  Carlo Alberto Scirè1,13  | |
[1] Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen University, Copenhagen, Denmark;Department of Internal Medicine and Therapeutics, Università di Pavia, Pavia, Italy;Istituti Clinici Scientifici Maugeri IRCCS, Pavia, Italy;IRCCS Ospedale Galeazzi – Sant’Ambrogio, Rheumatology Department, Milan, Italy;IRCCS Ospedale Galeazzi – Sant’Ambrogio, Rheumatology Department, Milan, Italy;Department of Biomedical and Clinical Sciences, Università degli studi di Milano, Milan, Italy;Interdisciplinary Pain Medicine Unit, Rheumatology Section, Santa Maria Maddalena Hospital, Rovigo, Italy;Medicine and Pharmacology Department, The University of Western Australia, Murdoch, Perth, WA, Australia;Rheumatology Department, Instituto Nacional de Rehabilitacion, Mexico, Mexico;Rheumatology Division, Multispecialist Medical Department, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy;Rheumatology Division, Multispecialist Medical Department, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy;SIR Epidemiology, Research Unit, Milan, Italy;Rheumatology Unit, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona, Italy;Rheumatology, Fondazione Policlinico Universitario “Gemelli”, IRCCS, Rome, Italy;SIR Epidemiology, Research Unit, Milan, Italy;SIR Epidemiology, Research Unit, Milan, Italy;School of Medicine, University of Milano Bicocca, Milan, Italy; | |
关键词: ultrasound; calcium pyrophosphate crystal deposition; conventional radiography; systematic review; CPPD; chondrocalcinosis; | |
DOI : 10.3389/fmed.2023.1131362 | |
received in 2022-12-24, accepted in 2023-02-09, 发布年份 2023 | |
来源: Frontiers | |
【 摘 要 】
ObjectivesTo identify the prevalence of calcium pyrophosphate crystal deposition (CPPD) using ultrasound and conventional radiology at peripheral joints in patients with suspected or definite CPPD.MethodsA systematic literature search was performed in PubMed and Embase using pre-defined search strategies from inception to April 2021 to identify studies that evaluated conventional radiology and ultrasound in detecting CPPD at peripheral joints, including definite or suspected CPPD [Research question 1 (RQ1) and Research Question 2 (RQ2), respectively]. For the meta-analysis, the first, second, and third sub-analysis included studies with the knee, and knee or wrist as the index joint for CPPD (without restrictions on the reference standard) and synovial fluid analysis or histology as a reference standard (without restrictions on the index joint), respectively.ResultsOne-thousand eight hundred and twenty-seven manuscripts were identified, of which 94 articles were finally included. Twenty-two and seventy-two papers were included in RQ1 and RQ2, respectively. The knee had the highest prevalence for RQ1 and RQ2 by both conventional radiology and ultrasound, followed by the wrist with the highest prevalence for RQ1. The hand had the lowest CPPD prevalence. The third sub-analysis showed a higher CPPD prevalence on ultrasound than conventional radiology at the knee (only data available).ConclusionAmong all peripheral joints, the knees and wrists could be regarded as the target joints for CPPD detection by imaging. Furthermore, ultrasound seems to detect a higher number of calcium pyrophosphate deposits than conventional radiology, even when using a more restrictive reference standard.
【 授权许可】
Unknown
Copyright © 2023 Adinolfi, Sirotti, Sakellariou, Cipolletta, Filippucci, Porta, Zanetti, Ughi, Sarzi-Puttini, Scirè, Keen, Pineda, Terslev, D’Agostino and Filippou.
【 预 览 】
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