ApoE gene polymorphisms and metals and their interactions with cognitive function

BMC Medical Genomics

Research

Tingyu Mai¹  Jian Qin¹  Song Xiao¹  Zeyan Ye¹  Tingyu Luo¹  You Li¹  Kailian He¹  Zhiyong Zhang²  Shenxiang Huang³  Yanfei Wei³  Yinxia Lin³  Jianshen Cai³  Xiaoting Mo³  Qiumei Liu³  Xu Tang³  Dechan Tan⁴  Ruoyu Gou⁵ 

[1] Department of Environmental Health and Occupational Medicine, School of Public Health, Guilin Medical University, The Guangxi Key Laboratory of Environmental Exposomics and Entire Lifecycle Heath, Zhiyuan Road No.1, 541199, Guilin, Guangxi province, PR China;Department of Environmental Health and Occupational Medicine, School of Public Health, Guilin Medical University, The Guangxi Key Laboratory of Environmental Exposomics and Entire Lifecycle Heath, Zhiyuan Road No.1, 541199, Guilin, Guangxi province, PR China;Guangxi Health Commission Key Laboratory of Entire Lifecycle Health and Care, Guilin Medical University, Guilin, China;Department of Environmental and Occupational Health, Guangxi Medical University, 530021, Nanning, China;Guangzhou Huashang Vocational College, No.1 Huashang Road, Lihu Street, Zengcheng District, 511300, Guangzhou, Guangdong Province, China;School of Public Health, Ningxia Medical University, 750004, Yinchuan, Ningxia, China;

关键词: Apolipoprotein E;    ApoE;    Metallic elements;    Cognitive function;   

DOI  :  10.1186/s12920-023-01632-6

 received in 2023-05-17, accepted in 2023-08-14,  发布年份 2023

来源: Springer

【 摘 要 】

ObjectiveTo analyze the relationship between plasma metal elements, ApoE gene polymorphisms and the interaction between the two and impaired cognitive function in elderly population.MethodA stratified sample was drawn according to the age of the study population, and 911 subjects were included. Baseline information and health indicators were obtained, and cognitive function status was assessed by health examination, a general questionnaire and Mini-Mental Status Examination. Plasma metal elements were measured, and SNP typing was performed. Binary logistic regression was used to analyze the factors influencing cognitive function status and the association between the SNP genetic pattern of the ApoE gene and cognitive function.ResultsThe differences in gene frequencies and genotype frequencies of the ApoE rs7412 and rs7259620 genotype frequencies were statistically different between the cognitive impairment group and the control group (P < 0.05). statistically differences were found for the codominant model in rs7412-TT compared with the CC genotype (OR = 3.112 (1.159–8.359), P = 0.024) and rs7259620-AA compared with the GG genotype (OR = 1.588 (1.007–2.504), P = 0.047). Statistically differences were found in the recessive models rs7412-TT compared with (CC + CT) (OR = 2.979 (1.112–7.978), P = 0.030), rs7259620-AA compared with (GG + GA), and rs405509-GG compared with (TT + TG) (OR = 1.548(1.022–2.344), P = 0.039) all of which increased the risk of developing cognitive impairment. The differences in plasma Fe, Cu, and Rb concentrations between the case and control groups were significant (P < 0.05). The regression results showed that the plasma Cd concentrations in the Q1 range was a protective factor for cognitive function compared with Q4 (0.510 (0.291–0.892), P = 0.018). Furthermore, there was a multiplicative interaction between the codominant and recessive models for the Q2 concentrations of Cd and the rs7259620 loci, and the difference was significant, indicating increased risk of developing cognitive impairment (codominant model OR = 3.577 (1.496–8.555), P = 0.004, recessive model OR = 3.505 (1.479–8.307), P = 0.004). There was also a multiplicative interaction between Cd and the recessive model at the rs405509 loci, and the difference was significant, indicating increased risk of developing cognitive impairment (OR = 3.169 (1.400-7.175), P = 0.006).ConclusionThe ApoE rs7412, rs7259620 and rs405509 loci were associated with cognitive impairment in the elderly population, and there was an interaction between plasma metalloid Cd and the rs7259620 and rs405509 loci that increased the risk of cognitive impairment in the elderly population.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

12888_2023_5012_Article_IEq2.gif

40517_2023_261_Article_IEq36.gif

Fig. 1