Home treatment as an add-on to family-based treatment for adolescents with anorexia nervosa compared with standard family-based treatment and home-based stress reduction training: study protocol for a randomized clinical trial

Journal of Eating Disorders

Study Protocol

Natalie Fabijani¹  Nicole Besse-Flütsch¹  Gian Giacomo Ruschetti¹  Dagmar Pauli¹  Lukasz Smigielski¹  Claudia Bühlmann¹ 

[1] Department of Child and Adolescent Psychiatry, Psychiatric University Hospital Zürich, University of Zürich, Neumünsterallee 3, 8032, Zurich, Switzerland;

关键词: Eating disorders;    Home treatment;    Adolescents;    Family-based treatment;    Anorexia nervosa;    Randomized clinical trial;    Mindfulness-based stress reduction training;   

DOI  :  10.1186/s40337-023-00861-5

 received in 2023-03-24, accepted in 2023-08-04,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundFamily-based treatment (FBT) is currently the most effective evidence-based treatment approach for adolescents with anorexia nervosa (AN). Home treatment (HT) as an add-on to FBT (FBT-HT) has been shown to be acceptable, feasible and effective. The described three-arm randomized clinical trial (RCT) is intended to investigate whether FBT-HT demonstrates higher efficacy compared to standard outpatient FBT with supplemental mindfulness-based stress reduction training (FBT-MBSR).MethodsThis RCT compares FBT-HT to standard outpatient FBT and FBT-MBSR as a credible home-based control group in terms of efficacy and delivery. Adolescents with AN or atypical AN disorder (n = 90) and their parent(s)/caregiver(s) are to be randomly assigned to either FBT, FBT-HT or FBT-MBSR groups. Eating disorder diagnosis and symptomatology are to be assessed by eating disorder professionals using standardized questionnaires and diagnostic instruments (Eating Disorder Examination, Eating Disorder Inventory, Body Mass Index). In addition, parents and caregivers independently provide information on eating behavior, intrafamily communication, stress experience and weight. The therapeutic process of the three treatments is to be measured and assessed among both participants and care providers. The feasibility, acceptability and appropriateness can thus also be evaluated.DiscussionWe hypothesize that FBT-HT will be an acceptable, appropriate and feasible intervention and, importantly, will outperform both established FBT and FBT-MBSR in improving adolescent weight and negative eating habits. Secondary outcome measures include the reduction in the stress experienced by caregivers, as well as the regulation of perceived expressed emotions within the family, while the intrafamily relationships are hypothesized to mediate/moderate the effectiveness of FBT. The proposed study has the potential to enhance the scientific and clinical understanding of the efficacy of FBT for AN, including whether the addition of HT to FBT versus another home-based adjunct intervention improves treatment outcomes. Furthermore, the study aligns with public health priorities to optimize the outcomes of evidence-based treatments and integrate the community setting.Trial registration This study is registered at ClinicalTrials.gov (NCT05418075).

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

Fig. 5