Evaluation of calcification distribution by CT-based textural analysis for discrimination of immature teratoma

Journal of Ovarian Research

Research

Akari Nakamori¹  Hideaki Tsuyoshi¹  Tetsuji Kurokawa¹  Yoshio Yoshida¹  Makoto Orisaka¹  Tetsuya Tsujikawa² 

[1]Department of Obstetrics and Gynecology, Faculty of Medical Sciences, University of Fukui, 23-3 Shimoaizuki, Matsuoka, Eiheiji-Cho, 910-1193, Yoshida-Gun, Fukui, Japan

[2]Department of Radiology, Faculty of Medical Sciences, University of Fukui, 23-3 Shimoaizuki, Matsuoka, Eiheiji-Cho, 910-1193, Yoshida-Gun, Fukui, Japan

关键词: Mature teratoma;    Immature teratoma;    CT;    Fat;    Calcification;    Texture analysis;   

DOI  :  10.1186/s13048-023-01268-1

 received in 2023-04-17, accepted in 2023-08-22,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundMature and immature teratomas are differentiated based on tumor markers and calcification or fat distribution. However, no study has objectively quantified the differences in calcification and fat distributions between these tumors. This study aimed to evaluate the diagnostic potential of CT-based textural analysis in differentiating between mature and immature teratomas in patients aged < 20 years.Materials and methodsThirty-two patients with pathologically proven mature cystic (n = 28) and immature teratomas (n = 4) underwent transabdominal ultrasound and/or abdominal and pelvic CT before surgery. The diagnostic performance of CT for assessing imaging features, including subjective manual measurement and objective textural analysis of fat and calcification distributions in the tumors, was evaluated by two experienced readers. The histopathological results were used as the gold standard. The Mann–Whitney U test was used for statistical analysis.ResultsWe evaluated 32 patients (mean age, 14.5 years; age range, 6–19 years). The mean maximum diameter and number of calcifications of immature teratomas were significantly larger than those of mature cystic teratomas (p < 0.01). The mean number of fats of immature teratomas was significantly larger than that of mature cystic teratomas (p < 0.01); however, no significant difference in the maximum diameter of fats was observed. CT textural features for calcification distribution in the tumors showed that mature cystic teratomas had higher homogeneity and energy than immature teratomas. However, immature teratomas showed higher correlation, entropy, and dissimilarity than mature cystic teratomas among features derived from the gray-level co-occurrence matrix (GLCM) (p < 0.05). No significant differences were observed in the CT features of fats derived from GLCM.ConclusionOur results demonstrate that calcification distribution on CT is a potential diagnostic biomarker to discriminate mature from immature teratomas, thus enabling optimal therapeutic selection for patients aged < 20 years.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

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