Baseline vitamin D levels and functional outcome in thrombolyzed stroke patients

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery

Research

Manar Mahmoud AbdelAziz¹  Mohammed M. Masoud¹  Noha A. Abd ElMonem¹  Rash H. Soliman¹  Alshaimaa Yassin Ramadan¹ 

[1]Department of Neurology, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt

关键词: Ischemic stroke;    Vitamin D;    rt-PA;    Functional outcome;    Treatment complications;   

DOI  :  10.1186/s41983-023-00706-7

 received in 2022-12-20, accepted in 2023-07-10,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundThe primary treatment for acute ischemic stroke (AIS) patients is intravenous recombinant tissue plasminogen activator (IV rt-PA). A link between vitamin D insufficiency and worse post-stroke outcomes and more severe strokes was suggested. The present study aimed to assess the prognostic significance of baseline vitamin D levels in AIS patients treated with rt-PA. The present prospective study was conducted 66 patients with acute ischemic stroke within the therapeutic window and treated with rt-PA. Vitamin D levels were assessed using commercial double antibody sandwich enzyme linked immunosorbent assay. The primary study outcome is patient disability of any degree as assessed by the modified Rankin scale (mRS).ResultsThe present study included 66 ischemic stroke patients treated with rt-PA. At baseline, there were 37 patients (56.1%) with low vitamin D levels. Comparison between patients with normal and low vitamin D levels regarding baseline data revealed that the former group were significantly younger and had significantly smaller infarct size patients with normal vitamin D had significantly lower NIHSS at day 2 and day 7. Interestingly, patients with low vitamin D levels had significantly higher frequency of rt-PA related hemorrhage, higher frequency of chest infection, longer hospital stay and higher mRS at 90 days. Multivariate logistic regression analysis identified vitamin D level as significant predictor of functional outcome at 90 days.ConclusionsBaseline vitamin D levels is considered a significant predictor of functional outcome in AIS patients treated with rt-PA. It’s also related to infarct size and treatment complications.

【 授权许可】

CC BY   
© The Author(s) 2023