Vitamin D and idiopathic pulmonary fibrosis: a two-sample mendelian randomization study

BMC Pulmonary Medicine

Research

Haiyan Mao¹  Zhenye Xie¹  Fen Zhou¹  Tong Lin¹  Yuhong Jin¹ 

[1] Department of Critical Care Medicine, Ningbo Medical Center Lihuili Hospital, NO.57 Xingning Road, Ningbo, China;

关键词: Vitamin D;    Idiopathic pulmonary fibrosis;    Mendelian randomization;   

DOI  :  10.1186/s12890-023-02589-z

 received in 2023-04-27, accepted in 2023-07-30,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundA prospective study of multiple small samples found that idiopathic pulmonary fibrosis (IPF) is often accompanied by a deficiency in Vitamin D levels. However, the causal relationship between the two remains to be determined. Therefore, our study aims to investigate the causal effect of serum 1,25-hydroxyvitamin D (25(OH)D) on the risk of IPF through a two-sample Mendelian randomization (MR) analysis.MethodsThrough data analysis from two European ancestry-based genome-wide association studies (GWAS), including 401,460 individuals for 25(OH)D levels and 1028 individuals for IPF, we primarily employed inverse-variance weighted (IVW) to assess the causal effect of 25(OH)D levels on IPF risk. MR-Egger regression test was used to determine pleiotropy, and Cochran’s Q test was conducted for heterogeneity testing. Leave-one-out analysis was conducted to examine the robustness of the results.Results158 SNPs related to serum 25(OH)D were used as instrumental variables (IVs). The MR analyses revealed no evidence supporting a causal association between the level of circulating 25(OH)D and the risk of IPF. The IVW method [OR 0.891, 95%CI (0.523–1.518), P = 0.670]; There was no significant level of heterogeneity, pleiotropy and bias in IVs. Cochran’s Q test for heterogeneity (MR Egger P = 0.081; IVW P = 0.089); MR-Egger regression for pleiotropy (P = 0.774).ConclusionsThis MR Study suggests that genetically predicted circulating vitamin D concentrations in the general population are not causally related to IPF.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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