Characteristics and potential clinical applications of the extracellular vesicles of human pathogenic Fungi

BMC Microbiology

Review

Mujeeb ur Rahman¹  Qian Wang²  Yuneng Hua²  Xiumei Hu³  Lei Zheng³  Jingyu Wang³  Amir Ullah³  Yiyi Huang³  Kening Zhao⁴  Shafi Ullah⁵ 

[1] Biofuels Institute, School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang, China;Center for Clinical Laboratory, Zhujiang Hospital, Southern Medical University, Guangzhou, People’s Republic of China;Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China;Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China;La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia;Department of pharmacy, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, Pakistan;

关键词: Extracellular vesicles;    Fungi;    Biogenesis;    Composition;    Immunomodulation;    Biomarkers;    Therapeutic applications;   

DOI  :  10.1186/s12866-023-02945-3

 received in 2023-03-21, accepted in 2023-07-14,  发布年份 2023

来源: Springer

【 摘 要 】

Extracellular vesicles (EVs) are a heterogeneous group of lipid membrane-enclosed compartments that contain different biomolecules and are released by almost all living cells, including fungal genera. Fungal EVs contain multiple bioactive components that perform various biological functions, such as stimulation of the host immune system, transport of virulence factors, induction of biofilm formation, and mediation of host–pathogen interactions. In this review, we summarize the current knowledge on EVs of human pathogenic fungi, mainly focusing on their biogenesis, composition, and biological effects. We also discuss the potential markers and therapeutic applications of fungal EVs.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

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