The correlation between different antihypertensive treatments and prognosis of cardiovascular disease in hypertensive patients

BMC Cardiovascular Disorders

Research

Jing Wan¹  Baozhu Wei¹  Shengnan Liu¹  Fei Li¹  Chao Zhang²  Hua Shao³ 

[1] Department of Cardiovascular Medicine, Zhongnan Hospital of Wuhan University, Shuiguohu Street, Wuchang District, 430071, Wuhan City, Hubei Province, China;Department of Electrocardiogram, Zhongnan Hospital of Wuhan University, Wuhan City, China;Renmin Hospital of Wuhan University, Zhangzhidong Road, Wuchang District, 430071, Wuhan City, Hubei Province, China;

关键词: Hypertension;    Antihypertensive treatment;    Standard blood pressure control;    Adverse cardiovascular events;   

DOI  :  10.1186/s12872-023-03381-x

 received in 2023-02-16, accepted in 2023-07-05,  发布年份 2023

来源: Springer

【 摘 要 】

ObjectiveTo determine the association between different antihypertensive regimens and cardiovascular disease (CVD) outcomes in hypertensive patients.MethodThis single center retrospective cohort study analyzed 602 hypertensive patients with complete medical records at Zhongnan Hospital of Wuhan University, China, from January 2016 to November 2022. Baseline data and follow-up data of the included patients were collected, including demographic and clinical characteristics and laboratory results.ResultsDuring the 5-year follow-up period, CVD outcomes occurred in 244 hypertensive patients (40.53%). Compared with patients receiving regular antihypertensive treatment, the incidence of adverse cardiovascular events in patients receiving irregular antihypertensive treatment was significantly higher (62 [55.86%] vs 182 [37.07%], HR 1.642, 95% CI 1.227–2.197, p < 0.001). In subgroup analysis, the results showed that the incidence of CVD was not identical (χ2 = 9.170, p = 0.010). The incidence of adverse cardiovascular events was highest in the single-drug antihypertensive treatment group (43.60%), followed by the multi-drug combination group (41.51%), and lowest in the two-drug combination group (29.58%). Kaplan–Meier curve showed that hypertensive patients treated with two-drug combination antihypertensive had longer overall survival time. We further compared the incidence of CVD between standard blood pressure and intensive blood pressure control, and found no significant difference in the incidence of adverse cardiovascular events between treatment to a systolic blood pressure (SBP) target of less than 140 mmHg compared with a SBP target of less than 120 mmHg (105 [43.93%] vs 35 [29.66%], HR 1.334, 95% CI 0.908–1.961, p = 0.142).ConclusionThe incidence of adverse cardiovascular events was significantly different among different antihypertension treatments. Kaplan–Meier survival curve showed that hypertensive patients receiving two-drug combination antihypertensive treatment had longer overall survival time.

【 授权许可】

CC BY   
© The Author(s) 2023

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