Ethical, legal, regulatory, and policy issues concerning embryoids: a systematic review of the literature

Stem Cell Research & Therapy

Review

Kirstin R. W. Matthews¹  Grace Koster²  Ana S. Iltis²  Emily Reeves² 

[1] Baker Institute for Public Policy, Rice University, 77005, Houston, TX, USA;Center for Bioethics, Health and Society and Department of Philosophy, Wake Forest University, 27106, Winston-Salem, NC, USA;

关键词: Embryoids;    Embryos;    Ethics;    Pluripotent stem cells;    Social implications;    Synthetic embryos;   

DOI  :  10.1186/s13287-023-03448-8

 received in 2023-07-10, accepted in 2023-08-10,  发布年份 2023

来源: Springer

【 摘 要 】

Recent advances in methods to culture pluripotent stem cells to model human development have resulted in entities that increasingly have recapitulated advanced stages of early embryo development. These entities, referred to by numerous terms such as embryoids, are becoming more sophisticated and could resemble human embryos ever more closely as research progresses. This paper reports a systematic review of the ethical, legal, regulatory, and policy questions and concerns found in the literature concerning human embryoid research published from 2016 to 2022. We identified 56 papers that use 53 distinct names or terms to refer to embryoids and four broad categories of ethical, legal, regulatory, or policy considerations in the literature: research justifications/benefits, ethical significance or moral status, permissible use, and regulatory and oversight challenges. Analyzing the full range of issues is a critical step toward fostering more robust ethical, legal, and social implications research in this emerging area and toward developing appropriate oversight.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

Fig. 1

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