A study on the effect of natural products against the transmission of B.1.1.529 Omicron

Virology Journal

Review

Aya Misbah Hussien¹  Heba Bedair²  Wilgince Apollon³  Soumya Ghosh⁴  Morteza Saki⁵  Mahmoud Abdo⁶  Samar Sami Alkafaas⁷  Mohamed Hessien⁷  Abanoub Mosaad Abdallah⁸  Sara Samy Elkafas⁹  Helen Onyeaka^1,10  Samah A. Loutfy^1,11 

[1] Biotechnology Department at Institute of Graduate Studies and Research, Alexandria University, Alexandria, Egypt;Botany Department, Faculty of Science, Tanta University, Tanta, Egypt;Department of Agricultural and Food Engineering, Faculty of Agronomy, Universidad Autónoma de Nuevo León, Francisco Villa S/N, Ex-Hacienda El Canadá, 66050, General Escobedo, Nuevo León, Mexico;Department of Genetics, Faculty of Natural and Agricultural Sciences, University of the Free State, 9301, Bloemfontein, South Africa;Department of Microbiology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran;Division of Biochemistry, Department of Chemistry, Faculty of Science, Tanta University, Tanta, 31527, Egypt;Molecular Cell Biology Unit, Division of Biochemistry, Department of Chemistry, Faculty of Science, Tanta University, 31527, Tanta, Egypt;Narcotic Research Department, National Center for Social and Criminological Research (NCSCR), 11561, Giza, Egypt;Production Engineering and Mechanical Design Department, Faculty of Engineering, Menofia University, Menofia, Egypt;School of Chemical Engineering, University of Birmingham, B15 2TT, Edgbaston, Birmingham, UK;Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt;Nanotechnology Research Center, British University, Cairo, Egypt;

关键词: COVID-19;    Omicron;    Natural product;    In silico;    Vaccine;    Molecular docking;   

DOI  :  10.1186/s12985-023-02160-6

 received in 2023-03-29, accepted in 2023-08-15,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundThe recent outbreak of the Coronavirus pandemic resulted in a successful vaccination program launched by the World Health Organization. However, a large population is still unvaccinated, leading to the emergence of mutated strains like alpha, beta, delta, and B.1.1.529 (Omicron). Recent reports from the World Health Organization raised concerns about the Omicron variant, which emerged in South Africa during a surge in COVID-19 cases in November 2021. Vaccines are not proven completely effective or safe against Omicron, leading to clinical trials for combating infection by the mutated virus. The absence of suitable pharmaceuticals has led scientists and clinicians to search for alternative and supplementary therapies, including dietary patterns, to reduce the effect of mutated strains.Main bodyThis review analyzed Coronavirus aetiology, epidemiology, and natural products for combating Omicron. Although the literature search did not include keywords related to in silico or computational research, in silico investigations were emphasized in this study. Molecular docking was implemented to compare the interaction between natural products and Chloroquine with the ACE2 receptor protein amino acid residues of Omicron. The global Omicron infection proceeding SARS-CoV-2 vaccination was also elucidated. The docking results suggest that DGCG may bind to the ACE2 receptor three times more effectively than standard chloroquine.ConclusionThe emergence of the Omicron variant has highlighted the need for alternative therapies to reduce the impact of mutated strains. The current review suggests that natural products such as DGCG may be effective in binding to the ACE2 receptor and combating the Omicron variant, however, further research is required to validate the results of this study and explore the potential of natural products to mitigate COVID-19.Graphical abstract

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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