Properties of white matter tract diffusivity in children with developmental dyslexia and comorbid attention deficit/hyperactivity disorder

Journal of Neurodevelopmental Disorders

Research

Rose A. Sevcik¹  Jeffrey Malins²  Ryan J. Slaby³  Robin Morris⁴  C. Nikki Arrington⁴  Kenneth R. Pugh⁵ 

[1] Department of Psychology, Georgia State University, 140 Decatur St SE, 30303, Atlanta, GA, USA;Department of Psychology, Georgia State University, 140 Decatur St SE, 30303, Atlanta, GA, USA;GSU/Georgia Tech Center for Advanced Brain Imaging, 831 Marietta St NW, 30318, Atlanta, GA, USA;Department of Psychology, Georgia State University, 140 Decatur St SE, 30303, Atlanta, GA, USA;GSU/Georgia Tech Center for Advanced Brain Imaging, 831 Marietta St NW, 30318, Atlanta, GA, USA;Department of Psychology, University of Milano-Bicocca, Piazza Dell’ Ateneo Nuovo,1, 20126, Milan, Italy;Department of Psychology, Georgia State University, 140 Decatur St SE, 30303, Atlanta, GA, USA;GSU/Georgia Tech Center for Advanced Brain Imaging, 831 Marietta St NW, 30318, Atlanta, GA, USA;Georgia State University, Center for Translational Research in Neuroimaging and Data Science, 55 Park Place, 18th Floor, 30303, Atlanta, GA, USA;Yale University, Haskins Laboratories, 300 George Street, Suite 900, 06511, New Haven, CT, USA;

关键词: Dyslexia;    ADHD;    Comorbidity;    DTI;    White matter;    SLF;    FA;    Reading;    Attention;    Executive function;   

DOI  :  10.1186/s11689-023-09495-9

 received in 2023-02-17, accepted in 2023-07-11,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundDevelopmental dyslexia (DD) and attention deficit/hyperactivity disorder (ADHD) are highly comorbid neurodevelopmental disorders. Individuals with DD or ADHD have both been shown to have deficits in white matter tracts associated with reading and attentional control networks. However, white matter diffusivity in individuals comorbid with both DD and ADHD (DD + ADHD) has not been specifically explored.MethodsParticipants were 3rd and 4th graders (age range = 7 to 11 years; SD = 0.69) from three diagnostic groups ((DD (n = 40), DD + ADHD (n = 22), and typical developing (TD) (n = 20)). Behavioral measures of reading and attention alongside measures of white matter diffusivity were collected for all participants.ResultsDD + ADHD and TD groups differed in mean fractional anisotropy (FA) for the left and right Superior Longitudinal Fasciculus (SLF)-Parietal Terminations and SLF-Temporal Terminations. Mean FA for the DD group across these SLF tracts fell between the lower DD + ADHD and higher TD averages. No differences in mean diffusivity nor significant brain-behavior relations were found.ConclusionsFindings suggest that WM diffusivity in the SLF increases along a continuum across DD + ADHD, DD, and TD.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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