3D biofabrication of diseased human skin models in vitro

Biomaterials Research

Review

Won-Woo Cho¹  Dong-Woo Cho¹  Wonbin Park¹  Minjun Ahn²  Byoung Soo Kim³  Min-Ju Choi⁴  Jae-Seong Lee⁴  Qiqi Gao⁵  Ge Gao⁵ 

[1] Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea;Medical Research Institute, Pusan National University, 626841, Yangsan, Kyungnam, Korea;Medical Research Institute, Pusan National University, 626841, Yangsan, Kyungnam, Korea;School of Biomedical Convergence Engineering, Pusan National University, Yangsan, Republic of Korea;School of Biomedical Convergence Engineering, Pusan National University, Yangsan, Republic of Korea;School of Medical Engineering, Beijing Institute of Technology, 100081, Beijing, China;

关键词: Skin engineering;    Diseased-skin model;    Tissue engineering;    In vitro modeling;   

DOI  :  10.1186/s40824-023-00415-5

 received in 2023-03-20, accepted in 2023-07-17,  发布年份 2023

来源: Springer

【 摘 要 】

Human skin is an organ located in the outermost part of the body; thus, it frequently exhibits visible signs of physiological health. Ethical concerns and genetic differences in conventional animal studies have increased the need for alternative in vitro platforms that mimic the structural and functional hallmarks of natural skin. Despite significant advances in in vitro skin modeling over the past few decades, different reproducible biofabrication strategies are required to reproduce the pathological features of diseased human skin compared to those used for healthy-skin models. To explain human skin modeling with pathological hallmarks, we first summarize the structural and functional characteristics of healthy human skin. We then provide an extensive overview of how to recreate diseased human skin models in vitro, including models for wounded, diabetic, skin-cancer, atopic, and other pathological skin types. We conclude with an outlook on diseased-skin modeling and its technical perspective for the further development of skin engineering.

【 授权许可】

CC BY   
© The Korean Society for Biomaterials 2023

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