Effect of two vitamin D repletion protocols on 24-h urine calcium in patients with recurrent calcium kidney stones and vitamin D deficiency: a randomized clinical trial

European Journal of Medical Research

Research

Lilit Sardari Masihi¹  Hossein Imani¹  Saba Jalali²  Sanaz Tavasoli³  Abbas Basiri³  Maryam Taheri³  Nasrin Borumandnia³ 

[1] Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Islamic Republic of Iran;Human Nutrition, Faculty of Land and Food Systems, University of British Columbia, Vancouver, CA, USA;Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, No.103, Shahid Jafari St., Pasdaran Ave., 1666668111, Tehran, Islamic Republic of Iran;

关键词: Vitamin D deficiency;    Urolithiasis;    24-h urine;    Hypercalciuria;   

DOI  :  10.1186/s40001-023-01226-z

 received in 2022-10-15, accepted in 2023-07-13,  发布年份 2023

来源: Springer

【 摘 要 】

ObjectivesTo evaluate the effects of two vitamin D repletion therapies (cholecalciferol) on serum levels of 25-hydroxyvitamin D (25(OH)D) and 24-h urine calcium in patients with recurrent calcium kidney stones and vitamin D deficiency (VDD).Design, setting, participantsA parallel-group randomized controlled clinical trial on patients who referred to Labbafinejad kidney stone prevention clinic, Tehran, Iran. From 88 recurrent calcium stone formers, 62 patients completed the study. The age of participants was 18–70 years who had serum 25(OH)D levels of 10–20 ng/ml.InterventionParticipants received oral cholecalciferol 2000 IU daily for 12 weeks or 50,000 IU weekly for 8 weeks.Main outcome measuresStudy variables including 24-h urine calcium, supersaturations of calcium oxalate and calcium phosphate, serum 25(OH)D and parathyroid hormone were measured at the beginning of the study and after 12 weeks.ResultsThe 24-h urine calcium significantly increased in both groups (β = 69.70, p < 0.001), with no significant difference between treatments. Both groups showed no significant change in the supersaturation levels of calcium oxalate and calcium phosphate. Serum levels of 25(OH)D increased significantly (β = 12.53, p < 0.001), with more increase in the 50,000 IU group (β = 3.46, p = 0.003). Serum parathyroid hormone decreased in both groups (p < 0.001).ConclusionsAlthough both treatment protocols increased 24-h urine calcium, they did not increase the supersaturation state of calcium oxalate or calcium phosphate.Trial registration IRCT20160206026406N4, 13/08/2019.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

Fig. 3