Protocol of a prospective community-based study about the onset and course of depression in a nationally representative cohort of adults in China: the China Depression Cohort Study-I

BMC Public Health

Study Protocol

Lingjiang Li¹  Zongchang Li¹  Shuiyuan Xiao¹  Xiaoping Wang¹  Xiaojie Zhang¹  Jiansong Zhou¹  Yusheng Tian²  Xuting Li²  Jun Liu³  Michael R. Phillips⁴ 

[1] Department of Psychiatry, National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital, Central South University, Changsha, China;Department of Psychiatry, National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital, Central South University, Changsha, China;Clinical Nursing Teaching and Research Section, The Second Xiangya Hospital, Central South University, Changsha, China;Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China;Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China;

关键词: Depression;    Prospective;    Cohort study;    Community-based;    China;   

DOI  :  10.1186/s12889-023-16542-6

 received in 2023-04-23, accepted in 2023-08-16,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundDepression is the second most important cause of disability worldwide. Reducing this major burden on global health requires a better understanding of the etiology, risk factors, and course of the disorder. With the goal of improving the prevention, recognition, and appropriate management of depressive disorders in China, the China Depression Cohort Study will establish a nationally representative sample of at least 85,000 adults (the China Depression Cohort Study-I) and 15,000 middle school students (the China Depression Cohort Study-II) and follow them over time to identify factors that influence the onset, characteristics, and course of depressive disorders. This protocol describes the China Depression Cohort Study-I.MethodsA multistage stratified random sampling method will be used to identify a nationally representative community-based cohort of at least 85,000 adults (i.e., ≥ 18 years of age) from 34 communities in 17 of mainland China’s 31 provincial-level administrative regions. Baseline data collection includes 1) demographic, social and clinical data, 2) diagnostic information, 3) biological samples (i.e., blood, urine, hair), 4) brain MRI scans, and 5) environmental data (e.g., community-level metrics of climate change, air pollution, and socio-economic characteristics). Baseline findings will identify participants with or without depressive disorders. Annual reassessments will monitor potential risk factors for depression and identify incident cases of depression. Cox Proportional-Hazards Regression, Network analysis, Disease trajectory modelling, and Machine learning prediction models will be used to analyze the collected data. The study’s main outcomes are the occurrence of depressive disorders; secondary outcomes include adverse behaviors (e.g., self-harm, suicide), the recurrence of depression and the incidence other mental disorders.DiscussionThe China Depression Cohort Study-I will collect a comprehensive, nationally representative set of individual-level and community-level variables over time. The findings will reframe the understanding of depression from a ‘biology-psychology-society’ perspective. This perspective will improve psychiatrists’ understanding of depression and, thus, promote the development of more effective subgroup-specific antidepressant drugs and other interventions based on the new biomarkers and relationships identified in the study.Trail registrationThe protocol has been registered on the Chinese Clinical Trial Registry (No. ChiCTR2200059016).

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

Fig. 2