Salmonella typhimurium necrotizing fasciitis: a case report

Journal of Medical Case Reports

Case Report

Radwan El Othman¹  Antoine Kharsa¹  Fatima Allaw²  Souheil Hallit³ 

[1] Department of Internal Medicine, American University of Beirut Medical Center (AUBMC), Beirut, Lebanon;Department of Internal Medicine, American University of Beirut Medical Center (AUBMC), Beirut, Lebanon;Division of Infectious Diseases, American University of Beirut Medical Center (AUBMC), Beirut, Lebanon;School of Medicine and Medical Sciences, Holy Spirit University of Kaslik, P.O. Box 446, Jounieh, Lebanon;Applied Science Research Center, Applied Science Private University, Amman, Jordan;Research Department, Psychiatric Hospital of the Cross, Jal Eddib, Lebanon;

关键词: Salmonella;    Salmonellosis;    Salmonella typhimurium;    Salmonella;    Bacteremia;    Necrotizing fasciitis;    Fusarium;    Immunodeficiency;    Case report;   

DOI  :  10.1186/s13256-023-04090-x

 received in 2022-11-29, accepted in 2023-07-20,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundNecrotizing fasciitis is an aggressive disease that causes necrosis in the muscular fascia and subcutaneous tissues. The infection spreads rapidly along the fascia and perifascial planes, followed by extension of the infection to nearby soft tissues and muscles. Necrotizing fasciitis can be attributed to different pathogens, namely Staphylococcus aureus, group A streptococci, and Clostridium perfringes. Only a few cases of skin and soft tissue infections from Salmonella species have been reported to date. Herein we report a case of Salmonella non-typhi necrotizing fasciitis, an exceedingly rare entity. This case report may serve as a potential management plan in similar cases in light of the scarcity of evidence.Case presentationA 20-year-old Caucasian male patient with congenital cardiac anomaly presented with diarrhea and unilateral lower extremity cellulitis causing septic shock. Cultures from blood and the bullae associated with the lower extremity cellulitis grew Salmonella typhimurium. Surgical debridement was performed. Intraoperative tissue cultures were positive for Salmonella typhimurium, and surgical pathology confirmed the diagnosis of necrotizing fasciitis. After a total of 6 weeks of appropriate antimicrobial therapy, another surgical debridement was executed for poor wound healing. New intraoperative cultures grew Fusarium species, and the patient received voriconazole with an adequate response. Immunologic studies showed humoral and cellular immunodeficiency.ConclusionIt is important to maintain a high index of suspicion for rare entities that can cause skin and soft tissue infections, such as Salmonella non-typhi, in particular in immunosuppressed patients where a delay in diagnosis and management may have significant morbidity and mortality.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

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