Growth differentiation factor-15 and circulating biomarkers as predictors of periodontal treatment effects in patients with periodontitis: a randomized-controlled clinical trial

BMC Oral Health

Research

Gianluca Martino Tartaglia¹  Gaetano Isola²  Simona Santonocito²  Antonino Lo Giudice²  Akhilanand Chaurasia³  Anand Marya⁴ 

[1]Department of Biomedical, Surgical and Dental Sciences, School of Dentistry, University of Milan, 20100, Milan, Italy

[2]Ospedale Maggiore Policlinico, Fondazione IRCCS Cà Granda, 20100, Milan, Italy

[3]Department of General Surgery and Surgical-Medical Specialties, School of Dentistry, University of Catania, Via S. Sofia 78, 95123, Catania, Italy

[4]Department of Oral Medicine, Faculty of Dental Sciences, King George’s Medical University, Lucknow, Uttar Pradesh, India

[5]Department of Orthodontics, University of Puthisastra Phnom Penh Combodia, 55180, Phnom Penh, Cambodia

[6]Center for Transdisciplinary Research, Saveetha Dental College, Saveetha Institute of Medical and Technical Science, Saveetha University, 600077, Chennai, India

关键词: Periodontitis;    Treatment outcome;    Growth differentiation factor 15;    Related circulating systemic risk;    Glutathione peroxidase 1;    c-reactive protein;    And surfactant protein D;    Serum;    Periodontal debridement;    Full mouth disinfection;    Clinical trial;   

DOI  :  10.1186/s12903-023-03237-y

 received in 2023-02-13, accepted in 2023-07-18,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundDuring the last decades, in patients with periodontitis, periodontal treatment has been shown to reduce the potential release of local and systemic biomarkers linked to an early risk of systemic inflammatory disorders. This study evaluated the efficacy of non-surgical-periodontal treatment (NSPT) on growth differentiation factor 15 (GDF-15) and related circulating biomarkers such as glutathione peroxidase 1 (GPx-1), c-reactive protein (hs-CRP), and surfactant protein D (SP-D) in periodontal patients and explored whether subjects who had high GDF-15 levels at baseline showed increased clinical benefits following NSPT at 6-months follow-up.MethodsFor this two-arm, parallel randomized clinical trial, patients with periodontitis were randomly allocated to receive quadrant scaling and root-planing (Q-SRP, n = 23, median age 51 years old) or full-mouth disinfection (FMD, n = 23, median age 50 years old) treatment. Clinical and periodontal parameters were recorded in all enrolled patients. The primary outcome was to analyse serum concentrations changes of GDF-15 and of GPx-1, hs-CRP, and SP-D at baseline and at 30, 90, and 180-days follow-up after NSPT through enzyme-linked immunosorbent assay (ELISA) and nephelometric assay techniques.ResultsIn comparison with FMD, patients of the Q-SRP group showed a significant improvement in clinical periodontal parameters (p < 0.05) and a reduction in the mean levels of GDF-15 (p = 0.005), hs-CRP (p < 0.001), and SP-D (p = 0.042) and an increase of GPx-1 (p = 0.025) concentrations after 6 months of treatment. At 6 months of treatment, there was a significant association between several periodontal parameters and the mean concentrations of GDF-15, GPx-1, hs-CRP, and SP-D (p < 0.05 for all parameters). Finally, the ANOVA analysis revealed that, at 6 months after treatment, the Q-SRP treatment significantly impacted the reduction of GDF-15 (p = 0.015), SP-D (p = 0.026) and the upregulation of GPx-1 (p = 0.045).ConclusionThe results evidenced that, after 6 months of treatment, both NSPT protocols improved the periodontal parameters and analyzed biomarkers, but Q-SRP was more efficacious than the FMD approach. Moreover, patients who presented high baseline GDF-15 and SP-D levels benefited more from NSPT at 6-month follow-up.Trial registrationNCT05720481.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

Fig. 1

Fig. 1