Outcomes of pregnancy in women with different types of pulmonary hypertension

BMC Cardiovascular Disorders

Research

Haitao Li¹  Jiangang Wang²  Yanna Li³  Jun Zhang³  Yang Liu⁴  Hong Gu⁴  Qiang Wang⁵ 

[1] Department of Adult Cardiac Center, Beijing Anzhen Hospital Affiliated to Capital Medical University, Chaoyang District, Beijing, China;Department of Adult Cardiac Center, Beijing Anzhen Hospital Affiliated to Capital Medical University, Chaoyang District, Beijing, China;Capital Medical University, Beijing Anzhen Hospital, No.2 An Zhen Road, Chaoyang District, 100029, Beijing, China;Department of Obstetrics and Gynecology, Beijing Anzhen Hospital Affiliated to Capital Medical University, Chaoyang District, Beijing, China;Department of Pediatric Cardiac Center, Beijing Anzhen Hospital Affiliated to Capital Medical University, Chaoyang District, Beijing, China;Department of Pediatric Cardiac Center, Beijing Anzhen Hospital Affiliated to Capital Medical University, Chaoyang District, Beijing, China;Capital Medical University, Beijing Anzhen Hospital, No.2 An Zhen Road, Chaoyang District, 100029, Beijing, China;

关键词: Pulmonary hypertension;    Pregnancy;    Congenital heart disease;    Left heart disease;    Eisenmanger syndrome;    Idiopathic pulmonary hypertension;   

DOI  :  10.1186/s12872-023-03423-4

 received in 2023-03-19, accepted in 2023-08-01,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundPulmonary hypertension (PH) is considered to increase maternal and fetal risk, and we attempt to explore pregnancy outcomes in women with different types of PH.MethodsWe retrospectively analyzed the clinical data of pregnant women with PH who were admitted to Anzhen Hospital from January 2010 to December 2019, and followed up on these parturients and their offspring.ResultsThree hundred and sixty-six pregnant women with PH were collected, including 265 pulmonary arterial hypertension (PAH) associated with congenital heart disease (CHD), 65 PH caused by left heart disease, 12 idiopathic PH, and 24 PH associated with other diseases. Maternal mean age was 28.4 ± 4.4 years and 72.1% were nulliparous. The estimated systolic pulmonary artery pressure was < 50 mmHg in 40.2% of patients, 50–70 mmHg in 23.2%, and > 70 mmHg in 36.6%. In more than 94% of women, a diagnosis of PH was made before pregnancy. During pregnancy, heart failure occurred in 15% of patients. Cesarean section was performed in 90.5% (20.4% emergency). Complications included fetal mortality (0.5%), preterm delivery (40.4%), and low birth weight (37.7%). A total of 20 mothers died (5.5%). The highest mortality rate was found in patients with idiopathic PH (4/12, 33.3%). A total of 12 children died (3.3%), 5 (1.4%) of them after discharge from the hospital, and 7 (1.9%) were in hospital.ConclusionsAlthough most of these women are fertile, PH does increase maternal and fetal risk. Women with idiopathic PH and Eisenmenger syndrome are not recommended to have children.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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