Propensity matched analysis examining the effect of passive reversal of direct oral anticoagulants on blood loss and the need for transfusions among traumatic geriatric hip fractures

European Journal of Medical Research

Research

David Bar-Or¹  Kristin Salottolo¹  Stephanie Jarvis¹  Therese Duane²  Michael Kelly³  Richard Meinig³  David Cornutt⁴  Bradley Woods⁵  Patrick McNair⁶  Nnamdi Nwafo⁷  Steven Morgan⁷  Paul Harrison⁸  Michelle Nentwig⁸ 

[1] Injury Outcomes Network (ION) Research, 501 East Hampden Ave, 80113, Englewood, CO, USA;Medical City Plano, 3901 West 15th Street, 75075, Plano, TX, USA;Penrose Hospital, 2222 N Nevada Ave, 80907, Colorado Springs, CO, USA;Regional West Medical Center, 4021 Ave B, 69361, Scottsbluff, NE, USA;Research Medical Center, 2316 East Meyer Blvd, 64132, Kansas City, MO, USA;St. Anthony Hospital, 11600 W 2nd Plaza, 80228, Lakewood, CO, USA;Swedish Medical Center, 501 East Hampden Ave, 80113, Englewood, CO, USA;Wesley Medical Center, 550 North Hillside St. Wichita, 67214, Wichita, KS, USA;

关键词: Direct oral anticoagulant;    Reversal;    Geriatric trauma;    Hip fractures;   

DOI  :  10.1186/s40001-023-01053-2

 received in 2022-02-01, accepted in 2023-02-08,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundReversal of direct oral anticoagulants (DOACs) is currently recommended prior to emergent surgery, such as surgical intervention for traumatic geriatric hip fractures. However, reversal methods are expensive and timely, often delaying surgical intervention, which is a predictor of outcomes. The study objective was to examine the effect of DOAC reversal on blood loss and transfusions among geriatric patients with hip fractures.MethodsThis retrospective propensity-matched study across six level I trauma centers included geriatric patients on DOACs with isolated fragility hip fractures requiring surgical intervention (2014–2017). Outcomes included: intraoperative blood loss, intraoperative pRBCs, and hospital length of stay (HLOS).ResultsAfter matching there were 62 patients (31 reversed, 31 not reversed), 29 patients were not matched. The only reversal method utilized was passive reversal (waiting ≥ 24 hours for elimination). Passively reversed patients had a longer time to surgery (mean, 43 vs. 18 hours, p < 0.01). Most patients (92%) had blood loss (90% passively reversed, 94% not reversed); the median volume of blood loss was 100 mL for both those groups, p = 0.97. Thirteen percent had pRBCs transfused (13% passively reversed and 13% not reversed); the median volume of pRBCs transfused was 525 mL for those passively reversed and 314 mL for those not reversed, p = 0.52. The mean HLOS was significantly longer for those passively reversed (7 vs. 5 days, p = 0.001).ConclusionsPassive DOAC reversal for geriatric patients with isolated hip fracture requiring surgery may be contributing to delayed surgery and an increased HLOS without having a significant effect on blood loss or transfusions. These data suggest that passive DOAC reversal may not be necessary prior to surgical repair of isolated hip fracture.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

Fig. 6