Nonspecific intraventricular conduction delay predicts the prognosis of dilated cardiomyopathy

BMC Cardiovascular Disorders

Research

Qianjun Liu¹  Dongsheng Jin²  Shihua Zhao³  Kai Yang³  Yong Yuan⁴  Weixiang Song⁵ 

[1] Department of Cardiology, Huadong Hospital Affiliated to Fudan University, 200040, Shanghai, China;Department of Diagnostic Imaging, Geriatric Hospital of Nanjing Medical University, 210024, Nanjing, China;Department of Magnetic Resonance Imaging, Cardiovascular Imaging and Intervention Center, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100037, Beijing, China;Department of Magnetic Resonance Imaging, Cardiovascular Imaging and Intervention Center, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100037, Beijing, China;Department of Diagnostic Imaging, Geriatric Hospital of Nanjing Medical University, 210024, Nanjing, China;Department of Radiology, Second Affiliated Hospital of Chongqing Medical University, 400010, Chongqing, China;

关键词: Prognosis;    Dilated cardiomyopathy;    Bundle branch block;    Magnetic resonance imaging;   

DOI  :  10.1186/s12872-023-03437-y

 received in 2023-02-27, accepted in 2023-08-08,  发布年份 2023

来源: Springer

【 摘 要 】

PurposeLeft bundle branch block (LBBB) has been confirmed to be independently associated with adverse outcomes in dilated cardiomyopathy (DCM). However, prognostic data on nonspecific intraventricular conduction delay (NSIVCD) are still limited and conflicting. We aimed to evaluate the prognosis of DCM with NSIVCD.MethodsA total of 548 DCM patients who underwent cardiovascular magnetic resonance imaging (CMR) from January 2016 to December 2017 were consecutively enrolled. The cohort was divided into four groups: 87 with LBBB, 27 with RBBB, 61 with NSIVCD, and 373 without intraventricular conduction delay (IVCD). After a median follow-up of 58 months (interquartile range: 47–65), 123 patients reached the composite endpoints, which included cardiovascular death, heart transplantation, and malignant arrhythmias. The associations between different patterns of IVCD and the outcomes of DCM were analysed by Kaplan‒Meier analysis and Cox proportional hazards regression analysis.ResultsOf 548 DCM patients, there were 398 males (72.6%), and the average age was 46 ± 15 years, ranging from 18 to 76 years. In Kaplan‒Meier analysis, patients with NSIVCD and LBBB showed higher event rates than patients without IVCD, while RBBB patients did not. By multivariate Cox regression analysis, LBBB, NSIVCD, NYHA class, left ventricular ejection fraction (LVEF), indexed left ventricular end-diastolic diameter (LVEDDI), percentage of late gadolinium enhancement mass (LGE%), and global longitudinal strain (GLS) were found to be independently associated with the outcomes of DCM.ConclusionsIn addition to LBBB, NSIVCD was an unfavourable prognostic marker in patients with DCM, independent of LVEDDI, NYHA class, LVEF, LGE%, and GLS.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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