Immune response in influenza virus infection and modulation of immune injury by viral neuraminidase

Virology Journal

Review

Zongde Zhang¹  Hongyu Jiang¹ 

[1] The People’s Hospital of Dayi Country, Chengdu, Sichuan, China;Inflammation and Allergic Diseases Research Unit, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China;School of Basic Medical Sciences, Southwest Medical University, Luzhou, Sichuan, China;

关键词: Influenza virus;    Neuraminidase;    Cytokine storm;    CD83;    Immune response;   

DOI  :  10.1186/s12985-023-02164-2

 received in 2023-02-10, accepted in 2023-08-16,  发布年份 2023

来源: Springer

【 摘 要 】

Influenza A viruses cause severe respiratory illnesses in humans and animals. Overreaction of the innate immune response to influenza virus infection results in hypercytokinemia, which is responsible for mortality and morbidity. The influenza A virus surface glycoprotein neuraminidase (NA) plays a vital role in viral attachment, entry, and virion release from infected cells. NA acts as a sialidase, which cleaves sialic acids from cell surface proteins and carbohydrate side chains on nascent virions. Here, we review progress in understanding the role of NA in modulating host immune response to influenza virus infection. We also discuss recent exciting findings targeting NA protein to interrupt influenza-induced immune injury.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

Fig. 4

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