Therapeutic application of regeneration-associated cells: a novel source of regenerative medicine

Stem Cell Research & Therapy

Review

Shuzo Kobayashi¹  Amankeldi A. Salybekov¹  Mehdi Hassanpour¹  Takayuki Asahara² 

[1] Kidney Disease and Transplant Center, Shonan Kamakura General Hospital, Kamakura, Japan;Shonan Research Institute of Innovative Medicine, Shonan Kamakura General Hospital, Kamakura, Japan;Shonan Research Institute of Innovative Medicine, Shonan Kamakura General Hospital, Kamakura, Japan;

关键词: Regeneration-associated cells;    Endothelial progenitor cells;    Cell therapy;    Regenerative medicine;   

DOI  :  10.1186/s13287-023-03428-y

 received in 2022-12-25, accepted in 2023-07-25,  发布年份 2023

来源: Springer

【 摘 要 】

Chronic diseases with comorbidities or associated risk factors may impair the function of regenerative cells and the regenerative microenvironment. Following this consideration, the vasculogenic conditioning culture (VCC) method was developed to boost the regenerative microenvironment to achieve regeneration-associated cells (RACs), which contain vasculogenic endothelial progenitor cells (EPCs) and anti-inflammatory/anti-immunity cells. Preclinical and clinical studies demonstrate that RAC transplantation is a safe and convenient cell population for promoting ischemic tissue recovery based on its strong vasculogenicity and functionality. The outputs of the scientific reports reviewed in the present study shed light on the fact that RAC transplantation is efficient in curing various diseases. Here, we compactly highlight the universal features of RACs and the latest progress in their translation toward clinics.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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Fig. 1