Burden of neglected tropical diseases and access to medicine and diagnostics in Ethiopia: a scoping review

Systematic Reviews

Research

Eyerusalem Getachew¹  Bethelhem Fekadu¹  Tsegahun Manyazewal¹  Charlotte Hanlon²  Agumasie Semahegn³  Abebaw Fekadu⁴  Esubalew Assefa⁵  Tassew Woldehanna⁶  Mesele Araya⁷  Gail Davey⁸  Munir Kassa⁹  Michael Hopkins^1,10 

[1] Centre for Innovative Drug Development and Therapeutic Trials for Africa (CDT-Africa), College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia;Centre for Innovative Drug Development and Therapeutic Trials for Africa (CDT-Africa), College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia;Centre for Global Mental Health, Health Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK;Department of Psychiatry, WHO Collaborating Centre for Mental Health Research and Capacity Building, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia;Centre for Innovative Drug Development and Therapeutic Trials for Africa (CDT-Africa), College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia;College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia;Department of Population, Family and Reproductive Health, School of Public Health, Unversity of Ghana, Accra, Ghana;Centre for Innovative Drug Development and Therapeutic Trials for Africa (CDT-Africa), College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia;Global Health & Infection Department, Brighton and Sussex Medical School, Brighton, UK;Department of Psychiatry, WHO Collaborating Centre for Mental Health Research and Capacity Building, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia;Centre for Innovative Drug Development and Therapeutic Trials for Africa (CDT-Africa), College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia;Health Economics and Policy Research Unit, Wolfson Institute of Population Health, Queen Mary University of London, London, UK;Department of Economics, Faculty of Arts and Social Sciences, The Open University, Milton Keynes, UK;College of Business and Economics, Addis Ababa University, Addis Ababa, Ethiopia;College of Business and Economics, Addis Ababa University, Addis Ababa, Ethiopia;Policy Studies Institute, Addis Ababa, Ethiopia;Global Health & Infection Department, Brighton and Sussex Medical School, Brighton, UK;School of Public Health, College of Health Science, Addis Ababa University, Addis Ababa, Ethiopia;Ministry of Health of Ethiopia, Addis Ababa, Ethiopia;Science Policy Research Unit, University of Sussex, Brighton, UK;

关键词: Neglected tropical diseases;    Diagnosis;    Treatment;    Medicine;    Scoping review;    Ethiopia;   

DOI  :  10.1186/s13643-023-02302-5

 received in 2022-10-11, accepted in 2023-07-28,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundMore than 1.7 billion people are affected by neglected tropical diseases (NTDs) worldwide. Forty percent of the NTD-affected people live in Africa with the poorest, most vulnerable, and hard to reach geographical areas. The NTDs cause significant social and economic burden and deepen marginalization and stigmatization. The World Health Organization’s current roadmap for NTD aims to prevent, control, eliminate, or eradicate 20 tropical diseases. Ethiopia experiences a high burden of these diseases, but current access to diagnostics, medicine, and/or care has been little explored to inform the country’s NTD strategic plan. The overall purpose of the scoping review was to map and characterize the burden of NTDs and challenges in access to diagnostics, medicine, and/or care in Ethiopia.MethodsA systematic search of evidence was conducted in PubMed, Cochrane Library, and Google Scholar from January 2000 until May 2022, without restrictions of language or study design. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Review was followed for screening of studies. Key findings were extracted and narrated qualitatively.ResultsThe search resulted in 4532 articles, of which 105 met the inclusion criteria and were included in the scoping review under three themes: burden of NTDs, access to diagnostics, medicine and/or care, and key barriers. Although gains have been made in the prevention and control of NTDs in Ethiopia, the burden remains high, and progress in access to diagnostics, medicine/drugs, and/or care is very slow. Poverty, poor quality of life, and underfunding of NTD programs decelerate the process of NTD elimination program in the country.ConclusionsThe scoping review identified a considerable number of studies on the burden of NTDs in Ethiopia and strategies for diagnosis, treatment, and/or care; however, there is a paucity of evidence on the suitability and potential benefits of novel diagnostic technologies and medicines in the country. A regular review and analysis of such country-level evidence is important to inform the country NTDs roadmap and local implementation strategies.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

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Fig. 1