Transjugular liver biopsy: enlarge the indications for liver biopsy with reliable diagnostic quality

BMC Gastroenterology

Research

Yan-Dan Zhong¹  Yi-Fan Hu¹  Miao-Yang Chen¹  Yong-Feng Yang¹  An-Yin Yang¹  Qing-Fang Xiong¹  Du-Xian Liu² 

[1] Department of liver diseases, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, No.1 Zhongfu Road, Gulou District, 210003, Nanjing, China;Department of pathology, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, No.1 Zhongfu Road, Gulou District, 210003, Nanjing, China;

关键词: Transjugular liver biopsy;    Complication;    Diagnostic efficiency;    Propensity score matching;   

DOI  :  10.1186/s12876-023-02917-x

 received in 2023-02-16, accepted in 2023-08-07,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundComplications and diagnostic efficiency for liver biopsy are main concerns for clinicians. This study aimed to assess the safety and efficacy of transjugular liver biopsy (TJLB) compared with percutaneous liver biopsy (PLB) when patients had equal level of liver function and number of passes, using propensity score matching (PSM).MethodsThe clinical and pathological data of patients who received TJLB or PLB between January 2012 and October 2022 were collected. Matching factors included age, gender, cirrhosis, portal hypertension, liver function, creatinine, number of passes, hemodialysis, history of anti-coagulation and anti-platelet, and comorbidities. Coagulation indexes were not considered as matching factors due to different indications of the two techniques.Results2711 PLBs and 30 TJLBs were evaluated. By PSM, 75 patients (50 PLBs, 25 TJLBs) were matched. The complication rates for TJLB and PLB were 4.0% (1/25) and 10.0% (5/50) (P > 0.05). Two PLBs had hepatic hemorrhage, one of which required only close monitoring (Grade 1) and the other needed hemostasis and rehydration therapy (Grade 2). The other 3 cases presented with mild abdominal pain (Grade 1). And only one TJLB presented with mild pain. The median number of complete portal tracts were 6.0 and 10.0 for TJLBs and PLBs (P < 0.05). Moreover, the median length of sample for TJLBs and PLBs were 10.0 and 16.5 mm (P < 0.05). The diagnostic efficiency of hepatopathy of unknown etiology of TJLB versus PLB groups before and after matching were 96.4% vs. 94.1% and 95.7% vs. 93.2%, respectively (P > 0.05).ConclusionTJLB is an effective invasive diagnostic procedure that expands indications for liver biopsy with reliable diagnostic quality.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

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