Association between fingertip-measured advanced glycation end products and cardiovascular events in outpatients with cardiovascular disease

Cardiovascular Diabetology

Research

Takuya Matsumoto¹  Kyo Shigeta¹  Junko Kikuchi¹  Taiki Tojo²  Miwa Ishida²  Kohki Ishida²  Kazuhiro Fujiyoshi³  Satoru Yamada⁴  Tomoya Hirai⁵ 

[1] Department of Cardiac Rehabilitation, Kitasato University Kitasato Institute Hospital, Minato-Ku, Japan;Department of Cardiovascular Medicine, Kitasato University Kitasato Institute Hospital, Minato-ku, Japan;Department of Cardiovascular Medicine, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, 252-0373, Sagamihara, Japan;Diabetes Center, Kitasato University Kitasato Institute Hospital, Minato-ku, Japan;Division of Rehabilitation, Department of Clinical Practice and Support, Hiroshima University Hospital, Hiroshima, Japan;Department of Cardiac Rehabilitation, Kitasato University Kitasato Institute Hospital, Minato-Ku, Japan;

关键词: Advanced glycation end products;    Noninvasive examination;    Fingertip;    Major adverse cardiac and cerebrovascular events;    Secondary prevention;    Outpatient cardiac rehabilitation;   

DOI  :  10.1186/s12933-023-01953-x

 received in 2023-05-01, accepted in 2023-08-08,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundThe accumulation of advanced glycation end products (AGEs) is associated with cardiovascular events in patients with cardiovascular disease (CVD). However, the relationship between the AGEs measured by an AGEs sensor noninvasively at the fingertip and prognosis in patients with CVD remains unclear. Therefore, this study aimed to determine the relationship between AGEs score and prognosis among patients with CVD.MethodsA total of 191 outpatients with CVD were included. AGEs score were measured using an AGEs sensor and the patients were classified into groups by the median value of AGEs score. The incidence of major adverse cardiovascular and cerebrovascular events (MACCE) at 30 months was compared between high- and low-AGEs score groups. In addition, receiver operating characteristic (ROC) curve analysis was used to calculate cutoff value for the AGEs score, which discriminates the occurrence of MACCE. Cox regression analysis was performed to identify the factors associated with the presence of MACCE. MACCE included cardiac death, myocardial infarction, percutaneous coronary intervention, heart failure, and stroke.ResultsAGEs score was normally distributed, with a median value of 0.51. No significant intergroup differences were found in laboratory findings, physical functions, or medications. The high-AGEs score group had a significantly higher incidence of MACCE than the low-AGEs score group (27.1 vs. 10.5%, P = 0.007). A high-AGEs score was a risk factor for MACCE (hazard ratio, 2.638; 95% confidence interval, 1.271–5.471; P = 0.009). After the adjustment for confounders other than 6-min walking distance, the AGEs score remained a factor associated with the occurrence of MACCE. The best cutoff AGEs score for the detection of MACCE was 0.51 (area under the curve, 0.642; P = 0.008; sensitivity, 72.2%; specificity, 54.8%).ConclusionsAGEs score measured at the fingertip in patients with CVD is associated with MACCE. AGEs score, which can be measured noninvasively and easily, may be useful as an assessment for the secondary prevention of CVD in patients with CVD.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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