MicroRNAs and pro-inflammatory cytokines as candidate biomarkers for recent-onset psychosis

BMC Psychiatry

Research

Negin Nezhadettehad¹  Ali Reza Shafiee-Kandjani¹  Dariush Shanebandi²  Mohammadbagher Hassanzadeh³  Hosein Azizi⁴  Richard Bruggeman⁵  Sara Farhang⁶ 

[1]Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

[2]Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

[3]Research Center of Psychiatry and Behavioral Sciences, Tabriz University of Medical Sciences, Tabriz, Iran

[4]Research Center of Psychiatry and Behavioral Sciences, Tabriz University of Medical Sciences, Tabriz, Iran

[5]Women’s Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

[6]University Medical Center Groningen, Groningen, Netherlands

[7]University Medical Center Groningen, Groningen, Netherlands

[8]Research Center of Psychiatry and Behavioral Sciences, Tabriz University of Medical Sciences, Tabriz, Iran

关键词: Schizophrenia;    miRNAs;    Psychoneuroimmunology;    Tumor necrosis factor-alpha;    Interleukin-1beta: Interleukin-6;   

DOI  :  10.1186/s12888-023-05136-6

 received in 2023-04-21, accepted in 2023-08-24,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundRecent studies on the schizophrenia spectrum and other psychotic disorders showed that alternation of immune system components, particularly microRNAs (miRNAs) and pro-inflammatory compounds, plays a significant role in developing the illness. The study aimed to evaluate serum expression of the miRNA-26a, miRNA-106a, and miRNA-125b as genetic factors and serum levels of IL-6, IL-1β, and TNF-α as pro-inflammatory factors in an IranianAzeri population.MethodsForty patients with recent-onset non-affective psychosis and 40 healthy people as a control group were involved. Expression levels of miRNAs and serum levels of the cytokines were measured using RT-qPCR and ELISA, respectively. T-test, receiver operating characteristics (ROC), and spearman correlation coefficient were carried out data analysis.ResultsFindings showed higher levels of IL-6, IL-1β, TNF-α, miR-26a, and miR-106a in the plasma of the patients’ group compared with the control. miRNA-26a showed a statistically significant higher level (p < .003) compared to the control group, with AUC = 0.84 (95% CI: 0.77 to 0.93, P < .001) and cut-off point = 0.17 in comparison to other miRNAs as mentioned above; in this regard, it might be a suggestive biomarker for schizophrenia in the early stage of the illness. Moreover, miRNAs’ expression level was not substantially associated with the level of any measured cytokines above.ConclusionsmiR-26a might be a suggestive biomarker for schizophrenia in the early stage of the illness. Given that the relationship between other miRNAs and cytokines is not yet well understood; accordingly, there are encouragement and support for continued research in this fascinating field.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

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