Dedifferentiated fat cells: current applications and future directions in regenerative medicine

Stem Cell Research & Therapy

Review

Yufei He¹  Jian Li¹  Junrong Cai¹  Yunjun Liao¹  Zhuokai Liang¹  Haojing Tang¹ 

[1] Department of Plastic and Reconstructive Surgery, Nanfang Hospital, Southern Medical University, 510515, Guangzhou, China;

关键词: Dedifferentiated fat cells;    Regenerative medicine;    Cell therapy;    Differentiation;    Secretion;    Redifferentiation;   

DOI  :  10.1186/s13287-023-03399-0

 received in 2022-10-31, accepted in 2023-06-13,  发布年份 2023

来源: Springer

【 摘 要 】

Stem cell therapy is the most promising treatment option for regenerative medicine. Therapeutic effect of different stem cells has been verified in various disease model. Dedifferentiated fat (DFAT) cells, derived from mature adipocytes, are induced pluripotent stem cells. Compared with ASCs and other stem cells, the DFAT cells have unique advantageous characteristics in their abundant sources, high homogeneity, easily harvest and low immunogenicity. The DFAT cells have shown great potential in tissue engineering and regenerative medicine for the treatment of clinical problems such as cardiac and kidney diseases, autoimmune disease, soft and hard tissue defect. In this review, we summarize the current understanding of DFAT cell properties and focus on the relevant practical applications of DFAT cells in cell therapy in recent years.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

Fig. 3