Loss-of-function variants in human C12orf40 cause male infertility by blocking meiotic progression

Cell Discovery

Correspondence

Wenbin He¹  Guangxiu Lu¹  Shao-Mei Fu²  Yong Li³  Chen Tan³  Chunbo Xie⁴  Chaofeng Tu⁴  Lanlan Meng⁴  Ge Lin⁴  Juan Du⁴  Yue-Qiu Tan⁵  Weili Wang⁵  Ying Chen⁶  Qifan Zhu⁷  Junfei Wen⁷  Jianglu Cheng⁷  Zeye Li⁷  Lan-Tao Gou⁷ 

[1] Clinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha, Hunan, China;Department of Breast Surgeon, The Obstetrics & Gynecology Hospital of Fudan University, Shanghai, China;Institute of Reproductive and Stem Cell Engineering, NHC Key Laboratory of Human Stem Cell and Reproductive Engineering, School of Basic Medical Sciences, Central South University, Changsha, Hunan, China;Institute of Reproductive and Stem Cell Engineering, NHC Key Laboratory of Human Stem Cell and Reproductive Engineering, School of Basic Medical Sciences, Central South University, Changsha, Hunan, China;Clinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha, Hunan, China;Institute of Reproductive and Stem Cell Engineering, NHC Key Laboratory of Human Stem Cell and Reproductive Engineering, School of Basic Medical Sciences, Central South University, Changsha, Hunan, China;Clinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha, Hunan, China;College of Life Science, Hunan Normal University, Changsha, Hunan, China;State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China;Chongqing Key Laboratory of Maternal and Fetal Medicine, Chongqing Medical University, Chongqing, China;State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China;University of Chinese Academy of Sciences, Beijing, China;

关键词: ;   

DOI  :  10.1038/s41421-023-00580-w

 received in 2022-10-31, accepted in 2023-06-18,  发布年份 2023

来源: Springer

【 授权许可】

CC BY   
© Center for Excellence in Molecular Cell Science, CAS 2023

【 图 表 】

Fig. 5

Fig. 1