Vitrectomy with sulfur hexafluoride versus air tamponade for idiopathic macular hole: a retrospective study

BMC Ophthalmology

Research

Chongya Dong¹  Huichao Yan²  Jinfeng Qu²  Jianhong Liang²  Hong Yin²  Enzhong Jin²  Mingwei Zhao²  Yuou Yao²  Chi Ren² 

[1] Department of Biostatistics, Peking University Clinical Research Institute, Beijing, China;Department of Ophthalmology, Peking University People’s Hospital, Xizhimen South Street 11, Xi Cheng District, 100044, Beijing, China;Eye Diseases and Optometry Institute, Beijing, China;Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, Beijing, China;College of Optometry, Peking University Health Science Center, Beijing, China;

关键词: Tamponade;    Gas;    Retinal perforations;    Surgery;   

DOI  :  10.1186/s12886-023-03049-2

 received in 2023-04-10, accepted in 2023-06-17,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundTo evaluate the effect of room air and sulfur hexafluoride (SF6) gas in idiopathic macular hole(MH)surgery.MethodsRetrospective, interventional, and comparative study. 238 eyes with the idiopathic macular hole that underwent pars plana vitrectomy, internal limiting membrane peeling, fluid-air exchange, and 20% SF6 (SF6 group:125 eyes) or room air tamponade (air group: 113 eyes) were reviewed. The primary outcome measure was the closure rate of primary surgery.ResultsThe baseline characteristics of the SF6 group and air group were comparable except for the hole size (479.90 ± 204.48 vs. 429.38 ± 174.63 μm, P = 0.043). The anatomical closure rate was 92.8% (116 / 125) with the SF6 group and 76.1% (86 / 113) with the air group (P < 0.001). A cut-off value of MH size to predict primary anatomical closure was 520 μm, which is based on the lower limit of 95% confidential interval of the MH size among the unclosed patients in the air group. There was no significant difference in anatomical closure rates between SF6 and air group (98.7% vs. 91.9%, P = 0.051) for MH ≤ 520 μm, whereas a significantly lower anatomical closure rate was shown in the air group than SF6 group (46.2% vs. 84.0%, P < 0.001) for MH > 520 μm.ConclusionSF6 exhibited more effectiveness than air to achieve a good anatomical outcome for its longer tamponade when MH > 520 μm.

【 授权许可】

CC BY   
© The Author(s) 2023