Low-dose aspirin, statins, and metformin and survival in patients with breast cancers: a Norwegian population-based cohort study

Breast Cancer Research

Research

Giske Ursin¹  L. Lukas Löfling²  Bettina Kulle Andreassen²  Nathalie C. Støer²  Edoardo Botteri³ 

[1] Cancer Registry of Norway, Oslo, Norway;Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway;Department of Preventive Medicine, University of Southern California, Los Angeles, USA;Department of Research, Cancer Registry of Norway, Postboks 5313 Majorstuen, 0304, Oslo, Norway;Department of Research, Cancer Registry of Norway, Postboks 5313 Majorstuen, 0304, Oslo, Norway;Section for Colorectal Cancer Screening, Cancer Registry of Norway, Oslo, Norway;

关键词: Breast cancer;    Low-dose aspirin;    Statins;    Metformin;    Survival;    Cohort;    Population-based;   

DOI  :  10.1186/s13058-023-01697-2

 received in 2023-06-15, accepted in 2023-08-14,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundPrevious studies assessed the prognostic effect of aspirin, statins, and metformin in breast cancer (BC) patients, with inconclusive results.MethodsWe performed a nationwide population-based cohort study to evaluate if post-diagnostic use of low-dose aspirin, statins, and metformin was associated with BC-specific survival. Women aged ≥ 50 years and diagnosed with BC in 2004–2017, who survived ≥ 12 months after diagnosis (follow-up started 12 months after diagnosis), were identified in the Cancer Registry of Norway. The Norwegian Prescription Database provided information on prescriptions. Multivariable Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the association between post-diagnostic use and BC-specific survival, overall and by oestrogen receptor (ER) status.ResultsA total of 26,190 patients were included. Of these, 5324 (20%), 7591 (29%), and 1495 (6%) were post-diagnostic users of low-dose aspirin, statins, and metformin, respectively. The median follow-up was 6.1 years, and 2169 (8%) patients died from BC. HRs for use, compared to no use, were estimated at 0.96 (95% CI 0.85–1.08) for low-dose aspirin (ER+: HR = 0.97, 95% CI 0.83–1.13; ER−: HR = 0.97, 95% CI 0.73–1.29, p value for interaction = 0.562), 0.84 (95% CI 0.75–0.94) for statins (ER+: HR = 0.95, 95% CI 0.82–1.09; ER−: HR = 0.77, 95% CI 0.60–1.00, p value for interaction = 0.259), and 0.70 (95% CI 0.51–0.96) for metformin (compared to use of non-metformin antidiabetics) (ER+: HR = 0.67, 95% CI 0.45–1.01; ER−: HR = 1.62, 95% CI 0.72–3.62, p value for interaction = 0.077).ConclusionWe found evidence supporting an association between post-diagnostic use of statins and metformin and survival, in patients with BC. Our findings indicate potential differences according to ER status.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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