Clinical characteristics of severe influenza virus-associated pneumonia complicated with bacterial infection in children: a retrospective analysis

BMC Infectious Diseases

Research

Jia-yi Lin¹  Lin Yuan²  Zhi-qiang Zhuo²  Si-si Li²  Qiong-yu Wang²  Xing-dong Wu²  Yong-mei Wang²  Min Zhang² 

[1] University of Manchester, Oxford Road, M13 9PL, Manchester, UK;Xiamen Children’s Hospital/Children’s Hospital of Fudan University at Xiamen, 361006, Xiamen, Fujian, China;

关键词: Bacteria;    Children;    Infection;    Influenza virus;    Pneumonia;   

DOI  :  10.1186/s12879-023-08536-x

 received in 2023-02-20, accepted in 2023-08-11,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundWe aimed to investigate the clinical characteristics of severe influenza virus-associated pneumonia complicated with bacterial infection in children.MethodsWe retrospectively analysed data concerning 64 paediatric patients with severe influenza virus-associated pneumonia who had been treated at our hospital. The patients were divided into observation (44 patients) and control (20 patients) groups, based on the presence or absence of concomitant bacterial infection, and clinical data were compared between the groups.ResultsThe mean age in the observation group was 2.71 ± 1.44 years, 42 (95.45%) were aged ≤ 5 years, and 18 (40.9%) had underlying diseases. The mean age in the control group was 4.05 ± 2.21 years, 13 (65%) were aged ≤ 5 years, and 3 (15%) had underlying diseases. There was a statistically significant difference in patient age and the proportion of patients with underlying diseases (P < 0.05). The observation group had higher duration of fever values, a higher number of patients with duration of fever ≥ 7 days, a higher incidence of gasping, and a higher incidence of seizures/consciousness disturbance, and the differences were statistically significant (P < 0.05). Secondary bacterial infections in the observation group were mainly due to gram-negative bacteria, with Haemophilus influenzae and Moraxella catarrhalis being the most common pathogens. The observation group had a higher proportion of patients treated in the paediatric intensive care unit and a longer hospital stay, and the differences were statistically significant (P < 0.05).ConclusionSevere influenza virus-associated pneumonia complicated with bacterial infection was more common in children aged ≤ 5 years. Younger patients with underlying diseases were more susceptible to bacterial infection (mainly due to gram-negative bacteria). The timely administration of neuraminidase inhibitors and antibiotics against susceptible bacteria is likely to help improve cure rates.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023