Body mass index and sex differences for mortality in hospitalized COVID-19 patients: a path analysis using a brazilian national database

BMC Public Health

Research

Maria Angelica Borges dos Santos¹  Phillipe Rodrigues²  Erika Cardoso dos Reis³  Sonia Regina Lambert Passos⁴  Jair Sindra Virtuoso Junior⁵  Joilson Meneguci⁶  Alexandre Palma⁶  Elma Lúcia de Freitas Monteiro⁶ 

[1] Escola Nacional de Saúde Pública Sergio Arouca (ENSP/FIOCRUZ), Rua Leopoldo Bulhões, 1480 - Manguinhos, Rio de Janeiro, Brasil;Escola de Educação Física e Desportos, Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho, 540 - Cidade Universitária da Universidade Federal do Rio de Janeiro, Rio de Janeiro - RJ, CEP: 21941-599, Rio de Janeiro, RJ, Brasil;Escola de Nutrição, Departamento de Nutrição Clínica e Social, Universidade Federal de Ouro Preto, Minas Gerais, Rua Dois, Campus Morro do Cruzeiro, CEP 35.400-000, Ouro Preto, Ouro Preto, MG, Brasil;Instituto Nacional de Infectologia Evandro Chagas (INI/FIOCRUZ), Av. Brasil, 4036, sala 201 A - Manguinhos, CEP: 21040-360, Rio de Janeiro, Brasil;Universidade Federal do Triângulo Mineiro, Programa de Pós Graduação em Atenção à Saúde, Av. Frei Paulino, nº 30 - Bairro Abadia, CEP: 38025-180, Uberaba, Minas Gerais, Brasil;Universidade Federal do Triângulo Mineiro. Programa de Pós Graduação em Atenção à Saúde, Av. Frei Paulino, nº 30 - Bairro Abadia, CEP: 38025-180, Uberaba, Minas Gerais, Brasil;

关键词: Obesity;    COVID-19;    Pandemics;   

DOI  :  10.1186/s12889-023-16218-1

 received in 2022-09-04, accepted in 2023-06-29,  发布年份 2023

来源: Springer

【 摘 要 】

Previous studies have shown that associations between obesity and other comorbidities favor worse outcomes in COVID-19. However, it is not clear how these factors interrelate and whether effects on men and women differ. We conducted an observational, cross-sectional study using a national COVID-19 inpatient database. We studied differences in direct and indirect effects of obesity and comorbidities according to sex and body mass index (BMI) categories in hospitalized COVID-19 patients in Brazil using path analysis models and logistic regression. For men, path analysis showed a direct association between BMI and death and a negative correlation of death and chronic cardiovascular disease (CCD). For women, the association of BMI and death was indirect, mediated by admission to the ICU and comorbidities and association with CCD was non-significant. In the logistic regression analyses, there was a positive association between death and BMI, age, diabetes mellitus, kidney and lung diseases and ICU admission. We highlight the need to consider the distinct impact of obesity and sex on COVID-19, of monitoring of BMI and of the design for specific male-targeted approaches to manage obesity.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

Fig. 1

Fig. 5