Clinical manifestation for immunoglobulin A deficiency: a systematic review and meta-analysis

Allergy, Asthma & Clinical Immunology

Review

Maria Marluce Dos Santos Vilela¹  Edyta Heropolitańska-Pliszka²  Molood Safarirad³  Ahmad Vosughimotlagh³  Niusha Sharifinejad⁴  Seyed Erfan Rasouli⁴  Hosein Rafiemanesh⁴  Gholamreza Azizi⁵  Atossa Madanipour⁶ 

[1] Center for Investigation in Pediatrics, Pediatrics Department, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, SP, Brazil;Department of Immunology, Children’s Memorial Health Institute, Warsaw, Poland;Department of Pediatrics, North Khorasan University of Medical Sciences, Bojnurd, Iran;Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran;Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran;Department of Neurology, Thomas Jefferson University, Philadelphia, PA, USA;Student Research Committee, Alborz University of Medical Sciences, Karaj, Iran;

关键词: Immunoglobulin A deficiency;    Autoimmune disorders;    Infections;    Malignancy;    Allergic diseases;   

DOI  :  10.1186/s13223-023-00826-y

 received in 2022-10-11, accepted in 2023-07-17,  发布年份 2023

来源: Springer

【 摘 要 】

ObjectivesImmunoglobulin A deficiency (IgAD) is a common disease with an unknown genetic defect, characterized by the decreased or absent IgA with other isotypes normal, normal subclasses, and specific antibodies. Patients with this disorder represent a spectrum of clinical manifestations including infections, autoimmune disorders, malignancy, and allergic diseases. The current study aimed to evaluate their prevalence and categorized them.MethodsWe searched PubMed, Web of Science, and Scopus databases to find eligible studies from the earliest available date to January 2022 with standard keywords. Pooled estimates of clinical manifestations prevalence and the corresponding 95% confidence intervals were calculated using random-effects models.ResultsThe most prevalent clinical manifestations belonged to infection (64.8%) followed by allergic diseases (26.16%) and autoimmunity (22.0%), respectively. In selective IgA deficiency patients as the largest group of IgAD in current study, celiac disease (6.57%), Inflammatory bowel disease (4.01%), and rheumatoid arthritis (3.80%) were the most prevalent autoimmunity. Meanwhile, the most frequent infection was respiratory tract infection, fungal infection, and gastrointestinal infection at 50.74%, 18.48%, and 15.79%, respectively. In addition, the pooled prevalence of asthma, allergic rhinitis, and allergic conjunctivitis were 19.06%, 15.46%, and 11.68%, respectively which were reported as the most widespread allergic diseases.ConclusionsOur results showed that apart from undiagnosed IgAD patients, IgAD patients represent a wide range of clinical manifestations. Infection, allergy, and autoimmunity are the most common clinical manifestations. The concurrent presence of IgA and IgG subtypes deficiency could be associated with increased susceptibility to infection. Considering the probability of developing new clinical complications during follow-up, periodic assessments of IgAD patients should be inspected.

【 授权许可】

CC BY   
© Canadian Society of Allergy & Clinical Immunology 2023

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