Identification of TRPM2 as a prognostic factor correlated with immune infiltration in ovarian cancer

Journal of Ovarian Research

Research

Chunyan Wang¹  Xueqian Shuai²  Zhongping Cheng²  Li Liu²  Wei Huang²  Jing Guo²  Shupeng Liu²  Yuliang Wu²  Ning Luo²  Fanchun Yang² 

[1] Department of Obstetrics and Gynecology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, 301 Yanchang Road, 200072, Shanghai, China;Department of Obstetrics and Gynecology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, 301 Yanchang Road, 200072, Shanghai, China;Gynecologic Minimally Invasive Surgery Research Center, Tongji University School of Medicine, 1239 Siping Road, 200092, Shanghai, China;

关键词: Pan-cancer;    TCGA;    TRPM2;    Prognosis;    Immunology;    Pyroptosis;   

DOI  :  10.1186/s13048-023-01225-y

 received in 2022-10-17, accepted in 2023-06-24,  发布年份 2023

来源: Springer

【 摘 要 】

IntroductionOvarian cancer (OC) is one of the most common gynecologic malignant cancers with the current survival rate remaining low. TRPM2 has been reported as a survival predictor in various cancers but not in OC. The aim of this study is to explore the role and its underlying mechanism of TRPM2 in OC.MethodsThe transcriptome data and clinical data were obtained from TCGA, GTEx, and GEO (GSE17260). DriverDBv3 and PrognoScan were used to analyze survival correlations. GSEA analysis was performed to uncover the underlying mechanism. The correlations between TRPM2 and immune score, immune cell infiltration were analyzed by TIMER2.0.ResultsTRPM2 was highly expressed in OC and high TRPM2 expression was related to the poor prognosis based on the Kaplan-Meier curves, univariate and multivariate analysis. The enrichment analysis suggested that TRPM2 was involved in immune-related pathways. Positive correlations were also observed between TRPM2 expression and immune score and immune cells covering B cells, T cells, macrophage, neutrophil, and myeloid dendritic cells. We also found that TRPM2 was positively related to immune checkpoints including ICOSLG, CD40, CD86, etc. TRPM2 expression had a positive correlation with M2 macrophage, but not with M1 macrophage. Besides, TRPM2 showed a strong positive correlation with pyroptosis-related genes including NLRP3, NLRC4, NOD2, NOD1, IL1B, GSDMD.ConclusionOur study demonstrated that TRPM2 is a poor prognostic prediction factor in ovarian cancer and is correlated to the immune microenvironment and pyroptosis. TRPM2 may act as a new immunotherapy target, which promoted the survival rate of OC patients.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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