Immediate visual reproduction negatively correlates with brain entropy of parahippocampal gyrus and inferior occipital gyrus in bipolar II disorder adolescents

BMC Psychiatry

Research

Weijia Gao¹  Guangming Lu²  Longchun Xu³  Qing Jiao⁴  Haiqin Liu⁴  Qingmin Meng⁵  Linyan Su⁶  Yongxin Guo⁷  Weifang Cao⁷  Jianfeng Qiu⁷  Liangfeng Kuang⁷  Dong Cui⁷ 

[1] Department of Child Psychology, The Children’ s Hospital, Zhejiang University School of Medicine, Hangzhou, China;Department of Medical Imaging, Jinling Hospital, Clinical School of Medical College, Nanjing University, Nanjing, China;Department of Radiology, The Second Affiliated Hospital of Shandong First Medical University, Tai’an, China;Department of Radiology, The Second Affiliated Hospital of Shandong First Medical University, Tai’an, China;School of Radiology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai’an, China;Department of interventional radiology, Taian Central Hospital, Tai’an, China;Key Laboratory of Psychiatry and Mental Health of Hunan Province, Mental Health Institute of the Second Xiangya Hospital, Central South University, Changsha, China;School of Radiology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai’an, China;

关键词: Bipolar II disorder adolescents;    Resting-state functional MRI;    Brain entropy;    Corticolimbic system;    Cortex;   

DOI  :  10.1186/s12888-023-05012-3

 received in 2023-03-04, accepted in 2023-07-07,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundBrain entropy reveals complexity and irregularity of brain, and it has been proven to reflect brain complexity alteration in disease states. Previous studies found that bipolar disorder adolescents showed cognitive impairment. The relationship between complexity of brain neural activity and cognition of bipolar II disorder (BD-II) adolescents remains unclear.MethodsNineteen BD-II patients (14.63 ±1.57 years old) and seventeen age-gender matched healthy controls (HCs) (14.18 ± 1.51 years old) were enlisted. Entropy values of all voxels of the brain in resting-state functional MRI data were calculated and differences of them between BD-II and HC groups were evaluated. After that, correlation analyses were performed between entropy values of brain regions showing significant entropy differences and clinical indices in BD-II adolescents.ResultsSignificant differences were found in scores of immediate visual reproduction subtest (VR-I, p = 0.003) and Stroop color-word test (SCWT-1, p = 0.015; SCWT-2, p = 0.004; SCWT-3, p = 0.003) between the two groups. Compared with HCs, BD-II adolescents showed significant increased brain entropy in right parahippocampal gyrus and right inferior occipital gyrus. Besides, significant negative correlations between brain entropy values of right parahippocampal gyrus, right inferior occipital gyrus and immediate visual reproduction subtest scores were observed in BD-II adolescents.ConclusionsThe findings of the present study suggested that the disrupted function of corticolimbic system is related with cognitive abnormality of BD-II adolescents. And from the perspective temporal dynamics of brain system, the current study, brain entropy may provide available evidences for understanding the underlying neural mechanism in BD-II adolescents.

【 授权许可】

CC BY   
© The Author(s) 2023

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