First report of primary testicular leiomyosarcoma in two dogs

BMC Veterinary Research

Case Report

Rafał Ciaputa¹  Małgorzata Kandefer-Gola¹  Marcin Nowak¹  Stanisław Dzimira¹  Kacper Żebrowski¹  Francesco Godizzi²  Valeria Grieco²  Eleonora Brambilla² 

[1]Department of Pathology, Division of Pathomorphology and Veterinary Forensics, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, C.K. Norwida 31, 50-375, Wroclaw, Poland

[2]Department of Veterinary Medicine and Animal Science, University of Milan, via dell’Università 6, 26900, Lodi, Italy

关键词: Testis;    Tumour;    Dog;    Sarcoma;    Immunohistochemistry;   

DOI  :  10.1186/s12917-023-03658-5

 received in 2022-08-09, accepted in 2023-07-13,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundTesticular tumours are common in dogs and, among them, interstitial cell tumours, seminomas and sustentacular cell tumours are the most reported. Mesenchymal testicular tumours are rarely reported in humans as in veterinary medicine where only three cases of sarcomas (leiomyomas and leomyosarcomas) have been described in two stallions and in a ram.Case presentationThe present cases regarded a 12-year-old mixed-breed dog and a 10-year-old American Staffordshire Terrier that underwent bilateral orchiectomy. Formalin fixed testes were referred for histopathological diagnosis. At gross examination, in one of the testes of both dogs, a white, firm and variably cystic testicular mass, effacing and replacing the testicular parenchyma was detected. Samples were collected from both neoplastic and contralateral testes, routinely processed for histology and serial sections were also examined immunohistochemically with primary antibodies against cytokeratins, vimentin, Von Willebrand factor, inhibin-α, α-smooth muscle actin, smooth muscle myosin and desmin. Histopathological features as well as the immunohistochemical results, positive for vimentin, actin, myosin and desmin, confirmed the mesenchymal origin and the myoid phenotype of both testicular tumours supporting the diagnoses of leiomyosarcoma.ConclusionsTo the authors knowledge these are the first cases of primary testicular sarcoma reported in the canine species. However, even rare, these tumours deserve to be considered in routine diagnosis when a testicular spindle cell tumour is observed. The immunohistochemical panel applied was useful to distinguish the present tumours from undifferentiated Sertoli cell tumours confirming the diagnosis of leiomyosarcoma.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

Fig. 1

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