Photodynamic therapy (PDT) for oral leukoplakia: a systematic review and meta-analysis of single-arm studies examining efficacy and subgroup analyses

BMC Oral Health

Research

Rui Zhang¹  Tong Gao²  Dan Wang³ 

[1] Department of General Stomatology, General Hospital of Ningxia Medical University, 750004, Yinchuan, China;Department of Prosthodontics, Affiliated Hospital of Yanan University, 716000, Shaanxi, China;Department of Stomatology, Qingtongxia Hospital of Traditional Chinese Medicine, 751600, Ningxia, China;

关键词: Photodynamic therapy;    Oral leukoplakia;    meta-analysis;    Single arm;    Subgroup analysis;   

DOI  :  10.1186/s12903-023-03294-3

 received in 2023-03-29, accepted in 2023-08-07,  发布年份 2023

来源: Springer

【 摘 要 】

ObjectiveThis study aims to evaluate the efficacy of photodynamic therapy (PDT) in the treatment of oral leukoplakia and explore the subgroup factors that may influence its effectiveness.MethodsA systematic search was conducted in PubMed, Embase, the Cochrane Library, and Web of Science databases to identify relevant studies. Meta-analysis was performed using Stata15.0 software. Cochran’s Q test and I2 statistics were used to evaluate heterogeneity, egger’s test was used to evaluate publication bias.ResultsThe analysis of 17 studies included in this study suggests that PDT may be effective in achieving complete response (CR) [ES = 0.50, 95%CI: (0.33,0.66)], partial response (PR) [ES = 0.42, 95%CI: (0.27,0.56)], no response (NR) [ES = 0.19, 95%CI: (0.11,0.27)]in patients with oral leukoplakia. The recurrence rate was also evaluated [ES = 0.13, 95%CI: (0.08,0.18)]. Subgroup analysis showed that various factors such as light source, wavelength, medium, duration of application, clinical and pathological diagnosis classification influenced efficacy of PDT. The lesion areas of the leukoplakia after treatment were reduced by 1.97cm2 compared with those before treatment.ConclusionOur findings show that PDT is a viable treatment for oral leukoplakia. However, the effectiveness of the therapy may depend on several factors, as suggested by our subgroup analyses. (Registration no. CRD42023399848 in Prospero, 26/02/2023)

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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