Beyond energy provider: multifunction of lipid droplets in embryonic development

Biological Research

Review

Yi Jin¹  Tai Li¹  Jian Wu²  Zhuqing Ren² 

[1] Key Laboratory of Agriculture Animal Genetics, Breeding and Reproduction of the Ministry of Education & Key Laboratory of Swine Genetics and Breeding of the Ministry of Agriculture and Rural Affairs, College of Animal Science, Huazhong Agricultural University, 430070, Wuhan, Hubei, P. R. China;Key Laboratory of Agriculture Animal Genetics, Breeding and Reproduction of the Ministry of Education & Key Laboratory of Swine Genetics and Breeding of the Ministry of Agriculture and Rural Affairs, College of Animal Science, Huazhong Agricultural University, 430070, Wuhan, Hubei, P. R. China;Frontiers Science Center for Animal Breeding and Sustainable Production, 430070, Wuhan, China;Hubei Hongshan Laboratory, Wuhan, China;

关键词: Lipid droplet;    Embryo;    Embryonic development;    Lipophagy;   

DOI  :  10.1186/s40659-023-00449-y

 received in 2023-02-11, accepted in 2023-06-23,  发布年份 2023

来源: Springer

【 摘 要 】

Since the discovery, lipid droplets (LDs) have been recognized to be sites of cellular energy reserves, providing energy when necessary to sustain cellular life activities. Many studies have reported large numbers of LDs in eggs and early embryos from insects to mammals. The questions of how LDs are formed, what role they play, and what their significance is for embryonic development have been attracting the attention of researchers. Studies in recent years have revealed that in addition to providing energy for embryonic development, LDs in eggs and embryos also function to resist lipotoxicity, resist oxidative stress, inhibit bacterial infection, and provide lipid and membrane components for embryonic development. Removal of LDs from fertilized eggs or early embryos artificially leads to embryonic developmental arrest and defects. This paper reviews recent studies to explain the role and effect mechanisms of LDs in the embryonic development of several species and the genes involved in the regulation. The review contributes to understanding the embryonic development mechanism and provides new insight for the diagnosis and treatment of diseases related to embryonic developmental abnormalities.

【 授权许可】

CC BY   
© The Author(s) 2023

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