Vasoreactivity of the optic nerve head, nailfold, and facial skin in response to cold provocation in normal-tension glaucoma patients

BMC Ophthalmology

Research

Takahiro Tomida¹  Toshihiko Ohtsuka¹  Miwako Shidomi²  Hisae Aoyagi²  Tomohiro Tsuda³  Takayuki Nishimura⁴  Nana Takahashi⁴  Yukihiro Shiga⁴  Naoki Kiyota⁴  Hiroshi Kunikata⁵  Toru Nakazawa⁶  Mai Yamazaki⁷ 

[1] Department of Advanced Development, Casio Computer Co., Ltd, Tokyo, Japan;Department of Health Science Research Planning Division, Rohto Pharmaceutical Co., Ltd, Osaka, Japan;Department of Internal Medicine and Food Development Division, Rohto Pharmaceutical Co., Ltd, Osaka, Japan;Department of Ophthalmology, Tohoku University Graduate School of Medicine, Miyagi, Japan;Department of Ophthalmology, Tohoku University Graduate School of Medicine, Miyagi, Japan;Department of Retinal Disease Control, Tohoku University Graduate School of Medicine, Miyagi, Japan;Department of Ophthalmology, Tohoku University Graduate School of Medicine, Miyagi, Japan;Department of Retinal Disease Control, Tohoku University Graduate School of Medicine, Miyagi, Japan;Department of Ophthalmic Imaging and Information Analytics, Tohoku University Graduate School of Medicine, Miyagi, Japan;Department of Advanced Ophthalmic Medicine, Tohoku University Graduate School of Medicine, Miyagi, Japan;Department of Ophthalmology, Tohoku University Graduate School of Medicine, Miyagi, Japan;Seiryo Eye Clinic, Miyagi, Japan;

关键词: Ocular blood flow;    Laser speckle flowgraphy;    Autoregulation;    Vasoreactivity;   

DOI  :  10.1186/s12886-023-03059-0

 received in 2023-03-16, accepted in 2023-06-23,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundThe dysfunction of optic nerve head (ONH) hemodynamics has been suggested to be involved in the pathogenesis of normal-tension glaucoma (NTG). The aim of this study was to compare vasoreactivity in the ONH, nailfold, and facial skin in response to cold-water provocation in NTG patients and healthy controls.MethodsWe performed cold-water provocation in 14 eyes of 14 NTG patients and 15 eyes of 15 age-matched control subjects. Laser speckle flowgraphy-derived tissue-area mean blur rate (MT), skin blood flowmetry-derived pulse wave amplitude (PA), nailfold capillaroscopy-derived nailfold capillary diameter, and other clinical parameters were recorded at baseline and 4 and 6 min after the cold stimulus. We compared changes (as percentages) in these variables in the NTG and control subjects with a linear mixed-effects model and evaluated correlations between these changes with Spearman’s rank correlation coefficient.ResultsThe interaction term between the NTG group (reference, control group) and the 4-min protocol step (reference, baseline) significantly affected the changes in MT, nailfold capillary diameter and PA (β = -9.51%, P = 0.017, β = -20.32%, P = 0.002; β =  + 18.06%, P = 0.017, respectively). The change in MT was positively correlated with the change in nailfold capillary diameter, and negatively correlated with the change in PA (r = 0.39, P = 0.036; r = -0.40, P = 0.031, respectively).ConclusionNTG patients showed abnormal vasoconstriction in the ONH and nailfold and vasodilation in the facial skin in response to cold-water provocation.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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