The leprosy reaction is associated with salivary anti-Porphyromonas gingivalis IgA antibodies

AMB Express

Original Article

Isaac Suzart Gomes-Filho¹  Soraya Castro Trindade²  Michelle Miranda Lopes Falcão²  Johelle Santana Passos-Soares³  Paulo Roberto LimaMachado⁴  José Tadeu Raynal Rocha Filho⁵  Lucas Pedreira de Carvalho⁵  Roberto Meyer Nascimento⁵  Elisangela Jesus de Campos⁶  Rebeca Pereira Bulhosa Santos⁷  Patrícia Mares de Miranda⁷  Mariana Costa Calheira⁷  Antonio Pedro Froes de Farias⁸  Taiana Peixoto⁹  Gregory John Seymour^1,10 

[1] Department of Health, State University of Feira de Santana, Feira de Santana, Brazil;Department of Health, State University of Feira de Santana, Feira de Santana, Brazil;Postgraduate Program in Immunology, Federal University of Bahia, Salvador, Brazil;Department of Health, State University of Feira de Santana, Feira de Santana, Brazil;Preventive Dentistry Department, Federal University of Bahia, Salvador, Brazil;Immunology Service, University Hospital Prof. Edgar Santos Federal University of Bahia, Salvador, Brazil;Immunology and Molecular Biology Laboratory, Federal University of Bahia, Salvador, Brazil;Oral Biochemistry Laboratory, Health Sciences Institute, Federal University of Bahia, Salvador, Brazil;Postgraduate Program in Immunology, Federal University of Bahia, Salvador, Brazil;Postgraduate Program in Immunology, Federal University of Bahia, Salvador, Brazil;Immunology and Molecular Biology Laboratory, Federal University of Bahia, Salvador, Brazil;School of Dentistry, Federal University of Bahia, Salvador, Brazil;School of Dentistry, The University of Queensland, Brisbane, Australia;

关键词: Saliva;    Periodontitis;    Humoral response;    Leprosy;   

DOI  :  10.1186/s13568-023-01576-1

 received in 2022-10-02, accepted in 2023-06-25,  发布年份 2023

来源: Springer

【 摘 要 】

The aim of the study was to evaluate the association between salivary anti-Porphyromonas gingivalis IgA antibodies and the leprosy reaction. The levels of salivary anti - P. gingivalis IgA antibodies, together with salivary flow and pH were measured in individuals diagnosed with leprosy and associated with the development of the leprosy reaction. Saliva was collected from 202 individuals diagnosed with leprosy at a reference leprosy treatment center, 106 cases with the leprosy reaction and 96 controls without the leprosy reaction. Anti - P. gingivalis IgA was evaluated by indirect immunoenzyme assay. Non-conditional logistic regression analysis was employed to estimate the association between antibody levels and the leprosy reaction. There was a positive statistically significant association between the levels of anti - P. gingivalis IgA and the presence of the leprosy reaction, controlling for confounders: age, sex, level of education and alcoholic beverage consumption: ORajusted: 2.55; IC 95%: 1.34–4.87. Individuals with leprosy who had high levels of salivary anti - P. gingivalis IgA had approximately twice as many chances of developing the leprosy reaction. The findings suggest a possible relationship between salivary anti - P. gingivalis IgA antibodies and the leprosy reaction.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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