Exploring the clinical application value of peripheral blood T lymphocyte subset in patients with asymptomatic omicron infection

European Journal of Medical Research

Research

Yuanhong Xu¹  Tuantuan Li²  Jing Xu³  Yong Gao⁴  XiaoWu Wang⁴ 

[1] Department of Clinical Laboratory, First Affiliated Hospital of Anhui Medical University, No. 218 of JiXi Road Hefei, 230022, Hefei, Anhui Province, China;Department of Clinical Laboratory, First Affiliated Hospital of Anhui Medical University, No. 218 of JiXi Road Hefei, 230022, Hefei, Anhui Province, China;Department of Clinical Laboratory, The Second People’s Hospital of Fuyang City (Fuyang Infectious Disease Clinical College of Anhui Medical University), 236000, Fuyang, Anhui Province, China;Department of Clinical Laboratory, Fuyang People’s Hospital (Anhui Medical University, Affiliated Fuyang Peoples Hospital), 236000, Fuyang, Anhui Province, China;Department of Clinical Laboratory, The Second People’s Hospital of Fuyang City (Fuyang Infectious Disease Clinical College of Anhui Medical University), 236000, Fuyang, Anhui Province, China;

关键词: Coronavirus disease 2019;    OMICRON variant strains;    CD3CD4+;    T lymphocytes;   

DOI  :  10.1186/s40001-023-01187-3

 received in 2022-08-10, accepted in 2023-06-22,  发布年份 2023

来源: Springer

【 摘 要 】

ObjectiveTo investigate the clinical significance and value of peripheral blood T lymphocyte subset in patients with asymptomatic novel coronavirus variant strains infection (OMICRON).MethodsA retrospective analysis of 281 patients with asymptomatic OMICRON infection who were admitted and isolated to the Fuyang Second People's Hospital from March to April 2022 was conducted. With 32 normal people as the control group, T lymphocytes of the two groups (CD3 + T, CD3 + CD4 + T, CD3 + CD8 + T) were analyzed and the differences between the two groups were analyzed. CD4 + T lymphocytes between patients with asymptomatic OMICRON infection and patients with mild COVID-19 infection in 2020 were analyzed and compared. Based on CD3 CD4 + T lymphocyte changes, lymphocyte reference range: CD3 CD4 + T lymphocyte count 404–1612/μL. Lower than 404 × 106/μL was defined as lymphocytopenia, patients were divided into the reduced group (138) and the normal group (143). The CT value of novel coronavirus nucleic acid (ORF1ab gene, N gene) and the time of viral shedding were compared between the two groups.ResultsDifferences in number of CD3 + T cells, CD3 + CD4 + T cells, and CD3 + CD8 + T cells were significant between both groups (P < 0.05), which were significantly higher in the normal population than in the patients with asymptomatic OMICRON infection. There was no significant difference in CD4 + T lymphocytes between patients with asymptomatic OMICRON infection and patients with mild COVID-19 infection in 2020 (P < 0.05). The novel coronavirus nucleic CT value was significantly lower in the CD3CD4 + T lymphocyte-reduced group than in the CD3CD4 + T lymphocyte-normal group (P < 0.05). Moreover, the time of viral shedding was significantly longer in the reduced group compared with the normal group (P < 0.05).ConclusionThe changing characteristics of the peripheral blood T lymphocyte subset count in patients with asymptomatic OMICRON infections can provide an important basis for the diagnosis and outcome of the asymptomatic OMICRON infection.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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