Ez-Metastasizing: The Crucial Roles of Ezrin in Metastasis

卷:12

Review

关键词: CIRCULATING TUMOR-CELLS;    TYROSINE KINASE SUBSTRATE;    BREAST-CANCER CELLS;    ERM PROTEINS;    NA+/H+ EXCHANGER;    PLASMA-MEMBRANE;    FOCAL ADHESION;    ACTIN CYTOSKELETON;    T-LYMPHOCYTES;    E-CADHERIN;   

DOI  :  10.3390/cells12121620

来源: SCIE

【 摘 要 】

Ezrin is the cytoskeletal organizer and functions in the modulation of membrane-cytoskeleton interaction, maintenance of cell shape and structure, and regulation of cell-cell adhesion and movement, as well as cell survival. Ezrin plays a critical role in regulating tumor metastasis through interaction with other binding proteins. Notably, Ezrin has been reported to interact with immune cells, allowing tumor cells to escape immune attack in metastasis. Here, we review the main functions of Ezrin, the mechanisms through which it acts, its role in tumor metastasis, and its potential as a therapeutic target.