Reciprocal Effect of Environmental Stimuli to Regulate the Adipogenesis and Osteogenesis Fate Decision in Bone Marrow-Derived Mesenchymal Stem Cells (BM-MSCs)

卷:12

Review

关键词: MAGNITUDE MECHANICAL SIGNALS;    ALCOHOL-INDUCED ADIPOGENESIS;    ACTIVATED-RECEPTOR-GAMMA;    STROMAL CELLS;    PPAR-GAMMA;    OSTEOBLAST DIFFERENTIATION;    PROMOTES OSTEOGENESIS;    ELECTROMAGNETIC-FIELDS;    ENDOCRINE DISRUPTOR;    GENE-EXPRESSION;   

DOI  :  10.3390/cells12101400

来源: SCIE

【 摘 要 】

Mesenchymal stem cells derived from bone marrow (BM-MSCs) can differentiate into adipocytes and osteoblasts. Various external stimuli, including environmental contaminants, heavy metals, dietary, and physical factors, are shown to influence the fate decision of BM-MSCs toward adipogenesis or osteogenesis. The balance of osteogenesis and adipogenesis is critical for the maintenance of bone homeostasis, and the interruption of BM-MSCs lineage commitment is associated with human health issues, such as fracture, osteoporosis, osteopenia, and osteonecrosis. This review focuses on how external stimuli shift the fate of BM-MSCs towards adipogenesis or osteogenesis. Future studies are needed to understand the impact of these external stimuli on bone health and elucidate the underlying mechanisms of BM-MSCs differentiation. This knowledge will inform efforts to prevent bone-related diseases and develop therapeutic approaches to treat bone disorders associated with various pathological conditions.