期刊论文详细信息
卷:12
The RUNX Family of Proteins, DNA Repair, and Cancer
Review
关键词: PROMOTES GENOMIC INSTABILITY;    ACUTE MYELOID-LEUKEMIA;    FANCONI-ANEMIA;    TRANSCRIPTION FACTOR;    OXIDATIVE STRESS;    GENE-EXPRESSION;    DOWN-REGULATION;    DAMAGE;    CELLS;    FUSION;   
DOI  :  10.3390/cells12081106
来源: SCIE
【 摘 要 】

The RUNX family of transcription factors, including RUNX1, RUNX2, and RUNX3, are key regulators of development and can function as either tumor suppressors or oncogenes in cancer. Emerging evidence suggests that the dysregulation of RUNX genes can promote genomic instability in both leukemia and solid cancers by impairing DNA repair mechanisms. RUNX proteins control the cellular response to DNA damage by regulating the p53, Fanconi anemia, and oxidative stress repair pathways through transcriptional or non-transcriptional mechanisms. This review highlights the importance of RUNX-dependent DNA repair regulation in human cancers.

【 授权许可】

   

  文献评价指标  
  下载次数:0次 浏览次数:2次