Tumor Microenvironment Role in Pancreatic Cancer Stem Cells

卷:12

Review

关键词: HYPOXIA-INDUCIBLE FACTORS;    ACUTE MYELOID-LEUKEMIA;    DENDRITIC CELLS;    DISTINCT POPULATIONS;    SIGNALING PATHWAYS;    MOLECULAR SUBTYPES;    HUMAN MACROPHAGES;    EXOSOMES;    EXPRESSION;    PROMOTES;   

DOI  :  10.3390/cells12121560

来源: SCIE

【 摘 要 】

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with a majority of patients presenting with unresectable or metastatic disease, resulting in a poor 5-year survival rate. This, in turn, is due to a highly complex tumor microenvironment and the presence of cancer stem cells, both of which induce therapy resistance and tumor relapse. Therefore, understanding and targeting the tumor microenvironment and cancer stem cells may be key strategies for designing effective PDAC therapies. In the present review, we summarized recent advances in the role of tumor microenvironment in pancreatic neoplastic progression.