Induced Pluripotent Stem Cells and Their Applications in Amyotrophic Lateral Sclerosis

卷:12

Review

关键词: C9ORF72 REPEAT EXPANSION;    MOTOR-NEURONS;    HUMAN FIBROBLASTS;    PHASE-SEPARATION;    OXIDATIVE STRESS;    MODELING ALS;    SPORADIC ALS;    TRANSPLANTATION;    PATIENT;    TRIAL;   

DOI  :  10.3390/cells12060971

来源: SCIE

【 摘 要 】

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that results in the loss of motor function in the central nervous system (CNS) and ultimately death. The mechanisms underlying ALS pathogenesis have not yet been fully elucidated, and ALS cannot be treated effectively. Most studies have applied animal or single-gene intervention cell lines as ALS disease models, but they cannot accurately reflect the pathological characteristics of ALS. Induced pluripotent stem cells (iPSCs) can be reprogrammed from somatic cells, possessing the ability to self-renew and differentiate into a variety of cells. iPSCs can be obtained from ALS patients with different genotypes and phenotypes, and the genetic background of the donor cells remains unchanged during reprogramming. iPSCs can differentiate into neurons and glial cells related to ALS. Therefore, iPSCs provide an excellent method to evaluate the impact of diseases on ALS patients. Moreover, patient-derived iPSCs are obtained from their own somatic cells, avoiding ethical concerns and posing only a low risk of immune rejection. The iPSC technology creates new hope for ALS treatment. Here, we review recent studies on iPSCs and their applications in disease modeling, drug screening and cell therapy in ALS, with a particular focus on the potential for ALS treatment.